Cell-cell fusion between eukaryotic cells is a general process involved in many
physiological and pathological conditions, including infections by bacteria, parasites, and …

Recent Ebola virus disease epidemics have highlighted the need for effective vaccines and
therapeutics to prevent future outbreaks. Antibodies are clearly critical for control of this …

Ebola virus (EboV) is a highly pathogenic enveloped virus that causes outbreaks of zoonotic
infection in Africa. The clinical symptoms are manifestations of the massive production of pro …

Summary Filoviruses, including Ebola and Marburg, cause fatal hemorrhagic fever in
humans and primates. Understanding how these viruses enter host cells could help to …

Ebola viruses (EBOVs) are responsible for repeated outbreaks of fatal infections, including
the recent deadly epidemic in West Africa. There are currently no approved therapeutic …

Ebola and Marburg filoviruses cause deadly outbreaks of haemorrhagic fever. Despite
considerable efforts, no essential cellular receptors for filovirus entry have been identified …

Ebola virus causes hemorrhagic fever with a high case fatality rate for which there is no
approved therapy. Two human monoclonal antibodies, mAb100 and mAb114, in …

Background Genomic studies of endangered species provide insights into their evolution
and demographic history, reveal patterns of genomic erosion that might limit their viability …

Respiratory syncytial virus (RSV) is an important cause of respiratory disease causing high
rates of hospitalizations in infants, significant morbidity in children and adults, and excess …

In order to replicate, most pathogens need to enter their target cells. Many viruses enter the
host cell through an endocytic pathway and hijack endosomes for their journey towards sites …