Statistical shape and appearance models: development towards improved osteoporosis care

L Grassi, SP Väänänen, H Isaksson - Current Osteoporosis Reports, 2021 - Springer
Abstract Purpose of Review Statistical models of shape and appearance have increased
their popularity since the 1990s and are today highly prevalent in the field of medical image …

Application of statistical shape modeling to the human hip joint: a sco** review

LG Johnson, S Bortolussi-Courval, A Chehil… - JBI Evidence …, 2023 - journals.lww.com
Objective: The objective of this sco** review was to identify all examples of the application
of statistical shape models to the human hip joint, with a focus on applications, population …

3D Finite Element Models Reconstructed From 2D Dual‐Energy X‐Ray Absorptiometry (DXA) Images Improve Hip Fracture Prediction Compared to Areal BMD in …

L Grassi, SP Väänänen, L Jehpsson… - Journal of Bone and …, 2023 - academic.oup.com
Bone strength is an important contributor to fracture risk. Areal bone mineral density (aBMD)
derived from dual‐energy X‐ray absorptiometry (DXA) is used as a surrogate for bone …

Stochastic PCA-based bone models from inverse transform sampling: proof of concept for mandibles and proximal femurs

G Pascoletti, A Aldieri, M Terzini, P Bhattacharya… - Applied Sciences, 2021 - mdpi.com
Featured Application Patient-specific, 3D CAD model of the mandible and of the proximal
femur can be obtained from a limited set of measurements; these models can be used for …

Improving the hip fracture risk prediction with a statistical shape-and-intensity model of the proximal femur

A Aldieri, P Bhattacharya, M Paggiosi, R Eastell… - Annals of biomedical …, 2022 - Springer
Severe predictions have been made regarding osteoporotic fracture incidence for the next
years, with major economic and social impacts in a worldwide greying society. However, the …

Statistical Properties of a Virtual Cohort for In Silico Trials Generated with a Statistical Anatomy Atlas

AA La Mattina, F Baruffaldi, M Taylor… - Annals of Biomedical …, 2023 - Springer
Osteoporosis-related hip fragility fractures are a catastrophic event for patient lives but are
not frequently observed in prospective studies, and therefore phase III clinical trials using …

Computer-aided diagnosis for China-Japan Friendship Hospital classification of necrotic femurs using statistical shape and appearance model based on CT scans

J Zhang, H Gong, P Ren, S Liu, Z Jia, P Shi - Medical & Biological …, 2024 - Springer
The purpose of this study is to quantify the three-dimensional (3D) structural morphology,
bone mineral density (BMD) distribution, and mechanical properties of different China-Japan …

A statistical shape analysis for the assessment of the main geometrical features of the distal femoral medullary canal

V Betti, A Aldieri, L Cristofolini - Frontiers in Bioengineering and …, 2024 - frontiersin.org
Statistical Shape Models (SSMs) are widely used in orthopedics to extract the main shape
features from bone regions (eg, femur). This study aims to develop an SSM of the femoral …

Assessment of bone strength and fracture behavior of degenerative vertebrae through quantifying morphology and density distribution

M Zhang, H Gong, M Zhang - Acta Mechanica Sinica, 2025 - Springer
Lumbar degeneration leads to changes in geometry and density distribution of vertebrae,
which could further influence the mechanical property and behavior. This study aimed to …

3D-DXA based finite element modelling for femur strength prediction: evaluation against QCT.

M Qasim, ML Picazo, CR Wills, J Noailly… - Journal of Clinical …, 2024 - Elsevier
Osteoporosis is characterised by the loss of bone density resulting in an increased risk of
fragility fractures. The clinical gold standard for diagnosing osteoporosis is based on the …