Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Alzheimer's disease (AD) is defined as a severe chronic degenerative neurological disease
in human. The pathogenic mechanism of AD has been convincingly elucidated by the …

Alzheimer's disease (AD) predominantly occurs as a late onset (LOAD) form involving
neurodegeneration and cognitive decline with progressive memory loss. Risk factors that …

Alzheimer's disease (AD) is a complex neurodegenerative disease, perturbing neuronal and
non-neuronal cell populations. In this study, using single-cell transcriptomics, we mapped all …

Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer's
disease, but their roles in disease have not been tested experimentally. We find that in …

Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …

Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …

Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a
unique molecular homeostatic 'signature', consisting of a specific transcriptional profile and …