Emergence of drug resistance has created unmet medical need for the development of new
classes of antibiotics. Discovery of new antibacterial agents with new mode of action …

The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

A class of quinazolone thiazoles was identified as new structural scaffolds for potential
antibacterial conquerors to tackle dreadful resistance. Some prepared compounds exhibited …

Antimicrobial resistance is an imminent threat worldwide. Methicillin-resistant
Staphylococcus aureus (MRSA) is one of the “superbug” family, manifesting resistance …

Despite the undisputed development of medicine, antibiotics still serve as first-choice drugs
for patients with infectious disorders. The widespread use of antibiotics results from a wide …

Infections caused by antibiotic-resistant bacteria (ARB) are one of the major global health
challenges of our time. In addition to develo** new antibiotics to combat ARB, sensitizing …

Available therapeutic strategies are urgently needed to conquer multidrug resistance of
MRSA. A visible effort was guided towards the advancement of novel antibacterial …

In this work, ruthenium (II)-catalyzed C–C/C–N annulation of 2-arylquinazolinones with
vinylene carbonate is reported to synthesize fused quinazolinones. This catalytic system …

The history of modern medicine cannot be written apart from the history of the antibiotics.
Antibiotics are cytotoxic secondary metabolites that are isolated from Nature. The …

We recently reported on the discovery of a novel antibacterial (2) with a 4 (3 H)-
quinazolinone core. This discovery was made by in silico screening of 1.2 million …