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Map** epigenetic modifications by sequencing technologies
X Chen, H Xu, X Shu, CX Song - Cell Death & Differentiation, 2025 - nature.com
The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …
Quantification and map** of RNA modifications
J ** with high-accuracy nanopore RNA basecalling models
In recent years, nanopore direct RNA sequencing (DRS) became a valuable tool for
studying the epitranscriptome, owing to its ability to detect multiple modifications within the …
studying the epitranscriptome, owing to its ability to detect multiple modifications within the …
Emerging and re-emerging themes in co-transcriptional pre-mRNA splicing
TJ Carrocci, KM Neugebauer - Molecular Cell, 2024 - cell.com
Proper gene expression requires the collaborative effort of multiple macromolecular
machines to produce functional messenger RNA. As RNA polymerase II (RNA Pol II) …
machines to produce functional messenger RNA. As RNA polymerase II (RNA Pol II) …
General principles and limitations for detection of RNA modifications by sequencing
Conspectus Among the many analytical methods applied to RNA modifications, a
particularly pronounced surge has occurred in the past decade in the field of modification …
particularly pronounced surge has occurred in the past decade in the field of modification …
Genomes in clinical care
O Riess, M Sturm, B Menden, A Liebmann… - Npj Genomic …, 2024 - nature.com
In the era of precision medicine, genome sequencing (GS) has become more affordable and
the importance of genomics and multi-omics in clinical care is increasingly being …
the importance of genomics and multi-omics in clinical care is increasingly being …
Integrative omics approaches to advance rare disease diagnostics
Over the past decade high‐throughput DNA sequencing approaches, namely whole exome
and whole genome sequencing became a standard procedure in Mendelian disease …
and whole genome sequencing became a standard procedure in Mendelian disease …
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies
S Oberdoeffer, WV Gilbert - Nature Reviews Molecular Cell Biology, 2024 - nature.com
RNA modifications are essential for human health—too much or too little of them leads to
serious illnesses ranging from neurodevelopmental disorders to cancer. Technical …
serious illnesses ranging from neurodevelopmental disorders to cancer. Technical …
Epigenetics and plant hormone dynamics: a functional and methodological perspective
J Rudolf, L Tomovicova, K Panzarova… - Journal of …, 2024 - academic.oup.com
Plant hormones, pivotal regulators of plant growth, development, and response to
environmental cues, have recently emerged as central modulators of epigenetic processes …
environmental cues, have recently emerged as central modulators of epigenetic processes …