Arterial smooth muscle cells (ASMCs), the predominant cell type within the arterial wall,
detect and respond to external mechanical forces. These forces can be derived from blood …

For correct chromosome segregation in mitosis, eukaryotic cells must establish chromosome
biorientation where sister kinetochores attach to microtubules extending from opposite …

Vascular smooth muscle cells (VSMCs) are the predominant cell type in the medial layer of
the aortic wall and normally exist in a quiescent, contractile phenotype where actomyosin …

Cross-linked actin networks are the primary component of the cell cytoskeleton and have
been the subject of numerous experimental and modeling studies. While these studies have …

Eukaryotic cells are mechanically supported by a polymer network called the cytoskeleton,
which consumes chemical energy to dynamically remodel its structure. Recent experiments …

Rapid advances in experimental biophysical techniques are generating a wealth of
information about the mechanical operation of the cellular cytoskeleton and its motors …

Extensive studies of growing axons have revealed many individual components and protein
interactions that guide neuronal morphogenesis. Despite this, however, we lack any clear …

Actin networks rely on nucleation mechanisms to generate new filaments because
spontaneous nucleation is kinetically disfavored. Branching nucleation of actin filaments by …

Simulating soft matter systems such as the cytoskeleton can enable deep understanding of
experimentally observed phenomena. One challenge of modelling such systems is realistic …

Stress fibers are actomyosin bundles that regulate cellular mechanosensation and force
transduction. Interacting with the extracellular matrix through focal adhesion complexes …