The nervous system governs both ontogeny and oncology. Regulating organogenesis
during development, maintaining homeostasis, and promoting plasticity throughout life, the …

Gliomas are a diverse group of primary central nervous system tumors that affect both
children and adults. Recent studies have revealed a dynamic cross talk that occurs between …

Tumor cells can “hijack” chemokine networks to support tumor progression. In this context,
the CC chemokine ligand 5/CC chemokine receptor type 5 (CCL5/CCR5) axis is gaining …

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a poor
prognosis, despite surgical resection combined with radio-and chemotherapy. The major …

Neurofibromatosis type 1 is a complex autosomal dominant disorder caused by germline
mutations in the NF1 tumour suppressor gene. Nearly all individuals with neurofibromatosis …

There is a growing recognition that gliomas are complex tumors composed of neoplastic and
non-neoplastic cells, which each individually contribute to cancer formation, progression …

Abstract In glioblastoma (GBM), tumor-associated macrophages (TAM) represent up to one
half of the cells of the tumor mass, including both infiltrating macrophages and resident brain …

One of the most common brain tumors in children and adults is glioma or astrocytoma. There
are few effective therapies for these cancers, and patients with malignant glioma fare poorly …

Extensive transcriptional and ontogenetic diversity exists among normal tissue-resident
macrophages, with unique transcriptional profiles endowing the cells with tissue-specific …

Neuronal activity is emerging as a driver of central and peripheral nervous system cancers.
Here, we examined neuronal physiology in mouse models of the tumor predisposition …