Melanoma

D Schadendorf, ACJ Van Akkooi, C Berking… - The Lancet, 2018 - thelancet.com
Cutaneous melanoma causes 55 500 deaths annually. The incidence and mortality rates of
the disease differ widely across the globe depending on access to early detection and …

Melanoma subtypes: genomic profiles, prognostic molecular markers and therapeutic possibilities

R Rabbie, P Ferguson, C Molina‐Aguilar… - The Journal of …, 2019 - Wiley Online Library
Melanoma is characterised by its ability to metastasise at early stages of tumour
development. Current clinico‐pathologic staging based on the American Joint Committee on …

The NF1 somatic mutational landscape in sporadic human cancers

C Philpott, H Tovell, IM Frayling, DN Cooper… - Human genomics, 2017 - Springer
Abstract Background Neurofibromatosis type 1 (NF1: Online Mendelian Inheritance in Man
(OMIM)# 162200) is an autosomal dominantly inherited tumour predisposition syndrome …

The mutational landscape of mucosal melanoma

KW Nassar, AC Tan - Seminars in cancer biology, 2020 - Elsevier
Mucosal melanoma is a rare and aggressive subtype of melanoma that has a less favorable
prognosis due to the lack of understanding and identification of oncogenic drivers. Recently …

Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma

J Ablain, M Xu, H Rothschild, RC Jordan, JK Mito… - Science, 2018 - science.org
Melanomas originating from mucosal surfaces have low mutation burden, genomic
instability, and poor prognosis. To identify potential driver genes, we sequenced hundreds of …

[HTML][HTML] Conjunctival melanoma: New insights in tumour genetics and immunology, leading to new therapeutic options

NJ Brouwer, RM Verdijk, S Heegaard… - Progress in Retinal and …, 2022 - Elsevier
Recent developments in oncology have led to a better molecular and cellular understanding
of cancer, and the introduction of novel therapies. Conjunctival melanoma (CoM) is a rare …

Advanced melanoma: current treatment options, biomarkers, and future perspectives

EA Rozeman, TJA Dekker, JBAG Haanen… - American Journal of …, 2018 - Springer
Malignant melanoma accounts for the highest number of deaths from skin cancer, and the
prognosis of patients with stage IV disease has historically been poor. Novel insights into …

Naturally occurring canine melanoma as a predictive comparative oncology model for human mucosal and other triple wild-type melanomas

B Hernandez, HA Adissu, BR Wei, HT Michael… - International journal of …, 2018 - mdpi.com
Melanoma remains mostly an untreatable fatal disease despite advances in decoding
cancer genomics and develo** new therapeutic modalities. Progress in patient care …

Alterations in key signaling pathways in sinonasal tract melanoma. A molecular genetics and immunohistochemical study of 90 cases and comprehensive review of …

M Chłopek, J Lasota, LDR Thompson… - Modern …, 2022 - nature.com
Sinonasal mucosal melanoma is a rare tumor arising within the nasal cavity, paranasal
sinuses, or nasopharynx (sinonasal tract). This study evaluated 90 cases diagnosed in 29 …

[HTML][HTML] Safety and efficacy of nivolumab in patients with rare melanoma subtypes who progressed on or after ipilimumab treatment: a single-arm, open-label, phase II …

P Nathan, PA Ascierto, J Haanen, E Espinosa… - European Journal of …, 2019 - Elsevier
Background Nivolumab has been widely studied in non-acral cutaneous melanoma;
however, limited data are available in other melanoma subtypes. We report outcomes by …