Melanoma
Cutaneous melanoma causes 55 500 deaths annually. The incidence and mortality rates of
the disease differ widely across the globe depending on access to early detection and …
the disease differ widely across the globe depending on access to early detection and …
Melanoma subtypes: genomic profiles, prognostic molecular markers and therapeutic possibilities
Melanoma is characterised by its ability to metastasise at early stages of tumour
development. Current clinico‐pathologic staging based on the American Joint Committee on …
development. Current clinico‐pathologic staging based on the American Joint Committee on …
The NF1 somatic mutational landscape in sporadic human cancers
C Philpott, H Tovell, IM Frayling, DN Cooper… - Human genomics, 2017 - Springer
Abstract Background Neurofibromatosis type 1 (NF1: Online Mendelian Inheritance in Man
(OMIM)# 162200) is an autosomal dominantly inherited tumour predisposition syndrome …
(OMIM)# 162200) is an autosomal dominantly inherited tumour predisposition syndrome …
The mutational landscape of mucosal melanoma
KW Nassar, AC Tan - Seminars in cancer biology, 2020 - Elsevier
Mucosal melanoma is a rare and aggressive subtype of melanoma that has a less favorable
prognosis due to the lack of understanding and identification of oncogenic drivers. Recently …
prognosis due to the lack of understanding and identification of oncogenic drivers. Recently …
Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma
Melanomas originating from mucosal surfaces have low mutation burden, genomic
instability, and poor prognosis. To identify potential driver genes, we sequenced hundreds of …
instability, and poor prognosis. To identify potential driver genes, we sequenced hundreds of …
[HTML][HTML] Conjunctival melanoma: New insights in tumour genetics and immunology, leading to new therapeutic options
NJ Brouwer, RM Verdijk, S Heegaard… - Progress in Retinal and …, 2022 - Elsevier
Recent developments in oncology have led to a better molecular and cellular understanding
of cancer, and the introduction of novel therapies. Conjunctival melanoma (CoM) is a rare …
of cancer, and the introduction of novel therapies. Conjunctival melanoma (CoM) is a rare …
Advanced melanoma: current treatment options, biomarkers, and future perspectives
EA Rozeman, TJA Dekker, JBAG Haanen… - American Journal of …, 2018 - Springer
Malignant melanoma accounts for the highest number of deaths from skin cancer, and the
prognosis of patients with stage IV disease has historically been poor. Novel insights into …
prognosis of patients with stage IV disease has historically been poor. Novel insights into …
Naturally occurring canine melanoma as a predictive comparative oncology model for human mucosal and other triple wild-type melanomas
Melanoma remains mostly an untreatable fatal disease despite advances in decoding
cancer genomics and develo** new therapeutic modalities. Progress in patient care …
cancer genomics and develo** new therapeutic modalities. Progress in patient care …
Alterations in key signaling pathways in sinonasal tract melanoma. A molecular genetics and immunohistochemical study of 90 cases and comprehensive review of …
M Chłopek, J Lasota, LDR Thompson… - Modern …, 2022 - nature.com
Sinonasal mucosal melanoma is a rare tumor arising within the nasal cavity, paranasal
sinuses, or nasopharynx (sinonasal tract). This study evaluated 90 cases diagnosed in 29 …
sinuses, or nasopharynx (sinonasal tract). This study evaluated 90 cases diagnosed in 29 …
[HTML][HTML] Safety and efficacy of nivolumab in patients with rare melanoma subtypes who progressed on or after ipilimumab treatment: a single-arm, open-label, phase II …
P Nathan, PA Ascierto, J Haanen, E Espinosa… - European Journal of …, 2019 - Elsevier
Background Nivolumab has been widely studied in non-acral cutaneous melanoma;
however, limited data are available in other melanoma subtypes. We report outcomes by …
however, limited data are available in other melanoma subtypes. We report outcomes by …