The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
Blood-to-brain communication in aging and rejuvenation
Aging induces molecular, cellular and functional changes in the adult brain that drive
cognitive decline and increase vulnerability to dementia-related neurodegenerative …
cognitive decline and increase vulnerability to dementia-related neurodegenerative …
Challenges and hopes for Alzheimer's disease
SA Tatulian - Drug discovery today, 2022 - Elsevier
Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …
effective disease-modifying agents for many reasons, including the substantial …
Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
Exerkines in health, resilience and disease
LS Chow, RE Gerszten, JM Taylor… - Nature Reviews …, 2022 - nature.com
The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …
Impaired insulin signalling and allostatic load in Alzheimer disease
The discovery of insulin in 1921 revolutionized the treatment of diabetes and paved the way
for numerous studies on hormone signalling networks and actions in peripheral tissues and …
for numerous studies on hormone signalling networks and actions in peripheral tissues and …
Exercise hormone irisin is a critical regulator of cognitive function
Identifying secreted mediators that drive the cognitive benefits of exercise holds great
promise for the treatment of cognitive decline in ageing or Alzheimer's disease (AD). Here …
promise for the treatment of cognitive decline in ageing or Alzheimer's disease (AD). Here …
Physical activity and muscle–brain crosstalk
BK Pedersen - Nature Reviews Endocrinology, 2019 - nature.com
Neurological and mental illnesses account for a considerable proportion of the global
burden of disease. Exercise has many beneficial effects on brain health, contributing to …
burden of disease. Exercise has many beneficial effects on brain health, contributing to …
[HTML][HTML] Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs
D da Luz Scheffer, A Latini - … et Biophysica Acta (BBA)-Molecular Basis of …, 2020 - Elsevier
A wide array of molecular pathways has been investigated during the past decade in order
to understand the mechanisms by which the practice of physical exercise promotes …
to understand the mechanisms by which the practice of physical exercise promotes …
Exercise benefits on Alzheimer's disease: State-of-the-science
PL Valenzuela, A Castillo-García, JS Morales… - Ageing research …, 2020 - Elsevier
Although there is no unanimity, growing evidence supports the value of regular physical
exercise to prevent Alzheimer's disease as well as cognitive decline in affected patients …
exercise to prevent Alzheimer's disease as well as cognitive decline in affected patients …