Liquid biopsy with circulating tumor DNA (ctDNA) profiling by next-generation sequencing
holds great promise to revolutionize clinical oncology. It relies on the basis that ctDNA …

Natural products with polypharmacological profiles have demonstrated promise as novel
therapeutics for various complex diseases, including cancer. Currently, many gaps exist in …

Sequencing has identified millions of somatic mutations in human cancers, but
distinguishing cancer driver genes remains a major challenge. Numerous methods have …

Cancer is thought to be caused by the accumulation of driver genetic mutations. Therefore,
identifying cancer driver genes plays a crucial role in understanding the molecular …

With expanding applications of next-generation sequencing in medical genetics, increasing
computational methods are being developed to predict the pathogenicity of missense …

Motivation Identifying genes that play a causal role in cancer evolution remains one of the
biggest challenges in cancer biology. With the accumulation of high-throughput multi-omics …

Artificial intelligence (AI) proves to have enormous potential in many areas of healthcare
including research and chemical discoveries. Using large amounts of aggregated data, the …

With the advances in high-throughput technologies, millions of somatic mutations have been
reported in the past decade. Identifying driver genes with oncogenic mutations from these …

Precision cancer medicine promises to tailor clinical decisions to patients using genomic
information. Indeed, successes of drugs targeting genetic alterations in tumors, such as …

Identifying cancer driver genes plays a curial role in the development of precision oncology
and cancer therapeutics. Although a plethora of methods have been developed to tackle this …