Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry
JE Hanson, H Yuan, RE Perszyk, TG Banke… - …, 2024 - nature.com
Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …
synaptic transmission, are widely distributed throughout the central nervous system, and …
Mechanisms of NMDA receptor regulation
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …
expressed in the central nervous system that play key role in brain development and …
Molecular mechanism of ligand gating and opening of NMDA receptor
Glutamate transmission and activation of ionotropic glutamate receptors are the fundamental
means by which neurons control their excitability and neuroplasticity. The N-methyl-d …
means by which neurons control their excitability and neuroplasticity. The N-methyl-d …
[HTML][HTML] Molecular mechanisms of rapid-acting antidepressants: new perspectives for develo** antidepressants
T Chen, L Cheng, J Ma, J Yuan, C Pi, L **ong… - Pharmacological …, 2023 - Elsevier
Major depressive disorder (MDD) is a chronic relapsing psychiatric disorder. Conventional
antidepressants usually require several weeks of continuous administration to exert …
antidepressants usually require several weeks of continuous administration to exert …
Major depressive disorder: hypothesis, mechanism, prevention and treatment
L Cui, S Li, S Wang, X Wu, Y Liu, W Yu… - … and Targeted Therapy, 2024 - nature.com
Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …
Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits
J Zhang, M Zhang, Q Wang, H Wen, Z Liu… - Nature Structural & …, 2023 - nature.com
Abstract N-methyl-d-aspartate (NMDA) receptors are heterotetramers comprising two GluN1
and two alternate GluN2 (N2A-N2D) subunits. Here we report full-length cryo-EM structures …
and two alternate GluN2 (N2A-N2D) subunits. Here we report full-length cryo-EM structures …
Structural insights into NMDA receptor pharmacology
C Zhou, N Tajima - Biochemical Society Transactions, 2023 - portlandpress.com
N-methyl-d-aspartate receptors (NMDARs) comprise a subfamily of ionotropic glutamate
receptors that form heterotetrameric ligand-gated ion channels and play fundamental roles …
receptors that form heterotetrameric ligand-gated ion channels and play fundamental roles …
Subtype-specific conformational landscape of NMDA receptor gating
J Bleier, PRF de Mendonca, CH Habrian, C Stanley… - Cell reports, 2024 - cell.com
N-methyl-D-aspartate receptors are ionotropic glutamate receptors that mediate synaptic
transmission and plasticity. Variable GluN2 subunits in diheterotetrameric receptors with …
transmission and plasticity. Variable GluN2 subunits in diheterotetrameric receptors with …
Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease
A Carles, A Freyssin, S Guehairia, T Reguero… - Alzheimer's Research & …, 2025 - Springer
Background Fluoroethylnormemantine (FENM), a new Memantine (MEM) derivative,
prevented amyloid-β [25–35] peptide (Aβ25–35)-induced neurotoxicity in mice, a …
prevented amyloid-β [25–35] peptide (Aβ25–35)-induced neurotoxicity in mice, a …
Bi-directional allosteric pathway in NMDA receptor activation and modulation
PA Bender, S Chakraborty, RJ Durham, V Berka… - Nature …, 2024 - nature.com
Abstract N-methyl-D-aspartate (NMDA) receptors are ionotropic glutamate receptors
involved in learning and memory. NMDA receptors primarily comprise two GluN1 and two …
involved in learning and memory. NMDA receptors primarily comprise two GluN1 and two …