Muscle specific signaling has been shown to originate from myofilaments and their
associated cellular structures, including the sarcomeres, costameres or the cardiac …

Titin, the so‐called “third filament” of the sarcomere, represents a difficult challenge for the
determination of damaging genetic variants. A single titin molecule extends across half the …

Titin is a giant protein in the sarcomere that plays an essential role in muscle contraction
with actin and myosin filaments. However, its utility goes beyond mechanical functions …

Mastigonemes are thread-like structures adorning the flagella of protists. In Chlamydomonas
reinhardtii, filamentous mastigonemes find their roots in the flagella's distal region …

The cardiac sarcomere is a cellular structure in the heart that enables muscle cells to
contract. Dozens of proteins belong to the cardiac sarcomere, which work in tandem to …

Titin is the third contractile filament in the sarcomere, and it plays a critical role in sarcomere
integrity and both passive and active tension. Unlike the thick and thin filaments, which are …

While protein refolding has been studied for over 50 years since the pioneering work of
Christian Anfinsen, there have been a limited number of studies correlating results between …

Titin, the largest muscle protein, plays an important role in passive tension, sarcomeric
integrity and cell signaling within the muscle. Recent work has also highlighted a role for titin …

The disordered PEVK region of titin contains two main structural motifs: PPAK and poly-E.
The distribution of these motifs in the PEVK region contributes to the elastic properties of this …

Giant modular sarcomeric proteins such as titin have come under increasing scrutiny for
their contributions to diseases such as skeletal and cardiac myopathies. Many variants in …