The thiopurine drugs—azathioprine (AZA), 6-mercaptopurine (6-MP), and thioguanine—are
widely used to treat malignancies, rheumatic diseases, dermatologic conditions …

The thiopurine drugs azathioprine and 6‐mercaptopurine (6‐MP) are well‐established in the
treatment of inflammatory bowel disease (IBD). However, there is a wide inter‐and intra …

The influence of genetic polymorphism in inosine triphosphate pyrophosphatase (ITPA) on
thiopurine‐induced adverse events has not been investigated in the context of combination …

Aliment Pharmacol Ther 2012; 35: 15–36 Summary Background Thiopurines represent an
effective and widely prescribed therapy in inflammatory bowel disease (IBD). Concerns …

Background One‐third of patients with inflammatory bowel disease (IBD) receiving
azathioprine (AZA) withdraw treatment due to side effects or lack of clinical response. Aim To …

BACKGROUND & AIMS: Ribavirin-induced anemia is one of the major causes of
discontinuation and dose reduction during anti-hepatitis C virus therapy. Factors influencing …

This review summarises clinical pharmacological aspects of thiopurines in the treatment of
chronic inflammatory bowel disease (IBD). Current knowledge of pharmacogenetically …

Background: Firm recommendations about the way thiopurine drugs are introduced and the
use of thiopurine methyltransferase (TPMT) and metabolite measurements during treatment …

Azathioprine is a thiopurine immunosuppressant drug that occupies an important place in
the management of many autoimmune and inflammatory skin diseases. Its parent drug 6 …

Background & Aims: The use of azathioprine (AZA) in inflammatory bowel disease (IBD)
patients is limited by toxicity, which occurs in up to 20% of treated patients. Mutations in the …