Current and possible future therapeutic options for Huntington's disease
MW Ferguson, CJ Kennedy… - Journal of central …, 2022 - journals.sagepub.com
Huntington's disease (HD) is an autosomal neurodegenerative disease that is characterized
by an excessive number of CAG trinucleotide repeats within the huntingtin gene (HTT). HD …
by an excessive number of CAG trinucleotide repeats within the huntingtin gene (HTT). HD …
Huntington's disease: Diagnosis and management
Huntington's disease (HD) is an inherited neurodegenerative disease characterised by
neuropsychiatric symptoms, a movement disorder (most commonly choreiform) and …
neuropsychiatric symptoms, a movement disorder (most commonly choreiform) and …
Comprehensive genetic diagnosis of tandem repeat expansion disorders with programmable targeted nanopore sequencing
I Stevanovski, SR Chintalaphani, H Gamaarachchi… - Science …, 2022 - science.org
More than 50 neurological and neuromuscular diseases are caused by short tandem repeat
(STR) expansions, with 37 different genes implicated to date. We describe the use of …
(STR) expansions, with 37 different genes implicated to date. We describe the use of …
Timing and impact of psychiatric, cognitive, and motor abnormalities in Huntington disease
B McAllister, JF Gusella, GB Landwehrmeyer, JM Lee… - Neurology, 2021 - AAN Enterprises
Objective To assess the prevalence, timing, and functional impact of psychiatric, cognitive,
and motor abnormalities in Huntington disease (HD) gene carriers, we analyzed …
and motor abnormalities in Huntington disease (HD) gene carriers, we analyzed …
Gait performance of adolescent mice assessed by the CatWalk XT depends on age, strain and sex and correlates with speed and body weight
C Pitzer, B Kurpiers, A Eltokhi - Scientific reports, 2021 - nature.com
The automatization of behavioral tests assessing motor activity in rodent models is important
for providing robust and reproducible results and evaluating new therapeutics. The CatWalk …
for providing robust and reproducible results and evaluating new therapeutics. The CatWalk …
[HTML][HTML] Huntington disease
A Ajitkumar, O De Jesus - StatPearls [Internet], 2023 - ncbi.nlm.nih.gov
Huntington Disease - StatPearls - NCBI Bookshelf US flag An official website of the United
States government Here's how you know NIH NLM Logo Access keys NCBI Homepage …
States government Here's how you know NIH NLM Logo Access keys NCBI Homepage …
Fisetin improves lead-induced neuroinflammation, apoptosis and synaptic dysfunction in mice associated with the AMPK/SIRT1 and autophagy pathway
W Yang, ZK Tian, HX Yang, ZJ Feng, JM Sun… - Food and chemical …, 2019 - Elsevier
Fisetin, a natural flavonoid found in plants, fruits and vegetables, exerts anti-cancer, anti-
oxidant, anti-inflammatory and anti-mitotic effects. The current study instigates the protective …
oxidant, anti-inflammatory and anti-mitotic effects. The current study instigates the protective …
Epilepsy in neurodegenerative diseases: related drugs and molecular pathways
A Cano, E Fonseca, M Ettcheto, E Sánchez-López… - Pharmaceuticals, 2021 - mdpi.com
Epilepsy is a chronic disease of the central nervous system characterized by an electrical
imbalance in neurons. It is the second most prevalent neurological disease, with 50 million …
imbalance in neurons. It is the second most prevalent neurological disease, with 50 million …
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders
Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …
Identifying treatment targets is challenging because the diseases are resulting from …
[PDF][PDF] Huntington Disease: mechanism of Pathogenesis and recent developments in its therapeutic strategies: a review
One of the leading causes of death apart from cancer is a neurodegenerative disease.
Huntington's disease (HD) is such that affects the neurons resulting from the programmed …
Huntington's disease (HD) is such that affects the neurons resulting from the programmed …