The evolution of AMPK and its homologs enabled exquisite responsivity and control of
cellular energetic homeostasis. Recent work has been critical in establishing the …

The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …

TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate-and Fe2+-
dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has …

RNA methylation, an epigenetic modification that does not alter gene sequence, may be
important to diverse biological processes. Protein regulators of RNA methylation include …

Mounting evidence points to alterations in mitochondrial metabolism in renal cell carcinoma
(RCC). However, the mechanisms that regulate the TCA cycle in RCC remain …

3-3s are abundant proteins that regulate essentially all aspects of cell biology, including cell
cycle, motility, metabolism, and cell death. 14-3-3s work by docking to phosphorylated …

Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic
changes play a key role in the immune response to bacteria, among which DNA …

Increased neurogenesis elicits antidepressive-like effects. The antidiabetic drug metformin
(Met) reportedly promotes hippocampal neurogenesis, which ameliorates spatial memory …

Hematopoietic stem cells (HSCs) are capable of regenerating the blood system, but the
instructive cues that direct HSCs to regenerate particular lineages lost to the injury remain …

The microtubule-associated protein tau pathologically accumulates and aggregates in
Alzheimer's disease (AD) and other tauopathies, leading to cognitive dysfunction and …