Model systems for regeneration: zebrafish

IJ Marques, E Lupi, N Mercader - Development, 2019 - journals.biologists.com
Tissue damage can resolve completely through healing and regeneration, or can produce
permanent scarring and loss of function. The response to tissue damage varies across …

Modeling inflammation in zebrafish for the development of anti-inflammatory drugs

Y ** of spinal cord growth and repair in living zebrafish larvae by Brillouin imaging
R Schlüßler, S Möllmert, S Abuhattum, G Cojoc… - Biophysical journal, 2018 - cell.com
The mechanical properties of biological tissues are increasingly recognized as important
factors in developmental and pathological processes. Most existing mechanical …

Transgenic fluorescent zebrafish lines that have revolutionized biomedical research

CP Choe, SY Choi, Y Kee, MJ Kim, SH Kim… - Laboratory Animal …, 2021 - Springer
Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish

D Wehner, TM Tsarouchas, A Michael, C Haase… - Nature …, 2017 - nature.com
The inhibitory extracellular matrix in a spinal lesion site is a major impediment to axonal
regeneration in mammals. In contrast, the extracellular matrix in zebrafish allows substantial …

Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina

DT White, S Sengupta, MT Saxena… - Proceedings of the …, 2017 - National Acad Sciences
Müller glia (MG) function as inducible retinal stem cells in zebrafish, completely repairing the
eye after damage. The innate immune system has recently been shown to promote tissue …

Decoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish

J Mi, KC Liu, O Andersson - Science Advances, 2023 - science.org
In contrast to mice, zebrafish have an exceptional yet elusive ability to replenish lost β cells
in adulthood. Understanding this framework would provide mechanistic insights for β cell …

CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury

M Keatinge, TM Tsarouchas, T Munir, NJ Porter… - PLoS …, 2021 - journals.plos.org
Zebrafish exhibit robust regeneration following spinal cord injury, promoted by macrophages
that control post-injury inflammation. However, the mechanistic basis of how macrophages …