The use of biomarkers as early warning systems in the evaluation of disease risk has
increased markedly in the last decade. Biomarkers are indicators of typical biological …

Network medicine is a rapidly evolving new field of medical research, which combines
principles and approaches of systems biology and network science, holding the promise to …

Cancer is a complex disease influenced by a heterogeneous landscape of both germline
genetic variants and somatic aberrations. While there is growing evidence suggesting an …

Corticotroph cells give rise to aggressive and rare pituitary neoplasms comprising ACTH-
producing adenomas resulting in Cushing disease (CD), clinically silent ACTH adenomas …

Common variable immunodeficiency (CVID) represents the largest group of primary
immunodeficiencies that may manifest with infections, inflammation, autoimmunity, and …

The human genome is traditionally represented as a DNA sequence of three billion base
pairs. However, its intricacies are captured by many more complex signals, representing …

The genetic predisposition to head and neck carcinomas (HNSCC) and how the known risk
factors (papillomavirus infection, alcohol, and tobacco consumption) contribute to the early …

In the past decade, the high throughput and low cost of sequencing/genoty** approaches
have led to the accumulation of a large amount of data from genome-wide association …

Background Understanding the role of circulating proteins in prostate cancer risk can reveal
key biological pathways and identify novel targets for cancer prevention. Methods We …

Exploring the molecular mechanisms of breast cancer is essential for the early prediction,
diagnosis, and treatment of cancer patients. The large scale of data obtained from the high …