[HTML][HTML] Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders
Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …
highlighting the need for improved drug treatments. In this review an overview of drugs …
Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders
MA Schiele, K Domschke - Genes, Brain and Behavior, 2018 - Wiley Online Library
The pathogenesis of anxiety disorders is multifactorial, involving complex interactions
between biological factors, environmental influences and psychological mechanisms …
between biological factors, environmental influences and psychological mechanisms …
The neurobiological mechanisms of generalized anxiety disorder and chronic stress
Two classification systems are now at the forefront of clinical psychiatric research:(1)
Diagnostic and Statistical Manual, Fifth Edition and (2) the National Institutes of Mental …
Diagnostic and Statistical Manual, Fifth Edition and (2) the National Institutes of Mental …
Prenatal influences on temperament development: The role of environmental epigenetics
MA Gartstein, MK Skinner - Development and Psychopathology, 2018 - cambridge.org
This review summarizes current knowledge and outlines future directions relevant to
questions concerning environmental epigenetics and the processes that contribute to …
questions concerning environmental epigenetics and the processes that contribute to …
Role of microRNAs in anxiety and anxiety-related disorders
CP Murphy, N Singewald - Behavioral neurogenomics, 2019 - Springer
MicroRNAs as critical regulators of gene expression important for functions including
neuronal development, synapse formation, and synaptic plasticity have been linked with the …
neuronal development, synapse formation, and synaptic plasticity have been linked with the …
Minimal traumatic brain injury causes persistent changes in DNA methylation at BDNF gene promoters in rat amygdala: a possible role in anxiety-like behaviors
Minimal traumatic brain injury (MTBI) often transforms into chronic neuropsychiatric
conditions including anxiety, the underlying mechanisms of which are largely unknown. In …
conditions including anxiety, the underlying mechanisms of which are largely unknown. In …
DNA methylation signatures in panic disorder
Panic disorder (PD) affects about four million Europeans, with women affected twice as likely
as men, causing substantial suffering and high economic costs. The etiopathogenesis of PD …
as men, causing substantial suffering and high economic costs. The etiopathogenesis of PD …
miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior
Abstract miR-132 and miR-212 are structurally-related microRNAs that are expressed from
the same non-coding transcript. Accumulating evidence has shown that the dysregulation of …
the same non-coding transcript. Accumulating evidence has shown that the dysregulation of …
Map** the past, present and future research landscape of paternal effects
Background Although in all sexually reproducing organisms an individual has a mother and
a father, non-genetic inheritance has been predominantly studied in mothers. Paternal …
a father, non-genetic inheritance has been predominantly studied in mothers. Paternal …
Anxiety disorders and general medical conditions: current research and future directions
Evidence that anxiety disorders are associated with general medical conditions is growing.
While it is known that medical and mental conditions are often comorbid, research …
While it is known that medical and mental conditions are often comorbid, research …