[HTML][HTML] Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders

SB Sartori, N Singewald - Pharmacology & therapeutics, 2019 - Elsevier
Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders

MA Schiele, K Domschke - Genes, Brain and Behavior, 2018 - Wiley Online Library
The pathogenesis of anxiety disorders is multifactorial, involving complex interactions
between biological factors, environmental influences and psychological mechanisms …

The neurobiological mechanisms of generalized anxiety disorder and chronic stress

MA Patriquin, SJ Mathew - Chronic Stress, 2017 - journals.sagepub.com
Two classification systems are now at the forefront of clinical psychiatric research:(1)
Diagnostic and Statistical Manual, Fifth Edition and (2) the National Institutes of Mental …

Prenatal influences on temperament development: The role of environmental epigenetics

MA Gartstein, MK Skinner - Development and Psychopathology, 2018 - cambridge.org
This review summarizes current knowledge and outlines future directions relevant to
questions concerning environmental epigenetics and the processes that contribute to …

Role of microRNAs in anxiety and anxiety-related disorders

CP Murphy, N Singewald - Behavioral neurogenomics, 2019 - Springer
MicroRNAs as critical regulators of gene expression important for functions including
neuronal development, synapse formation, and synaptic plasticity have been linked with the …

Minimal traumatic brain injury causes persistent changes in DNA methylation at BDNF gene promoters in rat amygdala: a possible role in anxiety-like behaviors

S Sagarkar, T Bhamburkar, G Shelkar… - Neurobiology of …, 2017 - Elsevier
Minimal traumatic brain injury (MTBI) often transforms into chronic neuropsychiatric
conditions including anxiety, the underlying mechanisms of which are largely unknown. In …

DNA methylation signatures in panic disorder

S Iurato, T Carrillo-Roa, J Arloth, D Czamara… - Translational …, 2017 - nature.com
Panic disorder (PD) affects about four million Europeans, with women affected twice as likely
as men, causing substantial suffering and high economic costs. The etiopathogenesis of PD …

miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior

S Aten, CE Page, A Kalidindi, K Wheaton, A Niraula… - …, 2019 - Elsevier
Abstract miR-132 and miR-212 are structurally-related microRNAs that are expressed from
the same non-coding transcript. Accumulating evidence has shown that the dysregulation of …

Map** the past, present and future research landscape of paternal effects

J Rutkowska, M Lagisz, R Bonduriansky, S Nakagawa - Bmc Biology, 2020 - Springer
Background Although in all sexually reproducing organisms an individual has a mother and
a father, non-genetic inheritance has been predominantly studied in mothers. Paternal …

Anxiety disorders and general medical conditions: current research and future directions

JP Aquin, R El-Gabalawy, T Sala, J Sareen - Focus, 2017 - Am Psychiatric Assoc
Evidence that anxiety disorders are associated with general medical conditions is growing.
While it is known that medical and mental conditions are often comorbid, research …