Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major
cause of morbidity and mortality globally. Compromised lung defences arising from …

Bronchiectasis is marked by bronchial dilatation, recurrent infections and significant
morbidity, underpinned by a complex interplay between microbial dysbiosis and immune …

Bronchiectasis, a progressive chronic airway disease, is characterized by microbial
colonization and infection. We present an approach to the multi-biome that integrates …

Neisseria species are frequently identified in the bronchiectasis microbiome, but they are
regarded as respiratory commensals. Using a combination of human cohorts, next …

Background Advanced chronic obstructive pulmonary disease (COPD) often leads to
hospitalisation and invasive aspergillosis (IA) is a serious complication. Aspergillus …

Allergy to airway-colonising, thermotolerant, filamentous fungi represents a distinct
eosinophilic endotype of often severe lung disease. This endotype, which particularly affects …

Introduction The chronic obstructive pulmonary disease (COPD) bacteriome associates with
disease severity, exacerbations and mortality. While COPD patients are susceptible to …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a crucial ion channel for
transport of chloride and bicarbonate anions. Functional roles of CFTR have been identified …

The term allergic fungal airways disease has a liberal definition based on IgE sensitisation
to thermotolerant fungi and evidence of fungal-related lung damage. It arose from a body of …

Fungal infections are estimated to be the main cause of death for more than 1.5 million
people worldwide annually. However, fungal pathogenicity has been largely neglected. This …