The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to
dynamic and functionally active organelles involved in a variety of cellular functions. Studies …

While the distant organ environment is known to support metastasis of primary tumors, its
metabolic roles in this process remain underdetermined. Here, in breast cancer models, we …

Acquisition of a lipid-laden phenotype by immune cells has been defined in infectious
diseases and atherosclerosis but remains largely uncharacterized in cancer. Here, in breast …

Nonalcoholic fatty liver disease (NAFLD) is an increasing global public health burden.
NAFLD is strongly associated with type 2 diabetes mellitus, obesity and cardiovascular …

Lipid droplets (LDs) are organelles that have evolved to store intracellular neutral lipids and
maintain cellular energy homeostasis. Once considered as inert fat particles, they have …

Nearly all living cells of organisms, including animals, protists, plants, and microorganisms,
synthesize lipid droplets (LDs), in which cholesteryl esters and triacylglycerol are stored …

This review discusses how lipophagy and cytosolic lipolysis degrade cellular lipids, as well
as how these pathway ys communicate, how they affect lipid metabolism and energy …

Much of the experimental evidence in the literature has linked altered lipid metabolism to
severe diseases such as cancer, obesity, cardiovascular pathologies, diabetes, and …

Metabolic myopathies are characterized by the deficiency or dysfunction of essential
metabolites or fuels to generate energy for muscle contraction; they most commonly manifest …