Long-range enhancer–promoter contacts in gene expression control
Spatiotemporal gene expression programmes are orchestrated by transcriptional
enhancers, which are key regulatory DNA elements that engage in physical contacts with …
enhancers, which are key regulatory DNA elements that engage in physical contacts with …
The Mediator complex as a master regulator of transcription by RNA polymerase II
The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …
Eukaryotic core promoters and the functional basis of transcription initiation
Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …
transcription start sites of protein-coding and non-coding genes that support the assembly of …
Mechanisms of enhancer action: the known and the unknown
Differential gene expression mechanisms ensure cellular differentiation and plasticity to
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …
cis-Regulatory Elements in Plant Development, Adaptation, and Evolution
cis-Regulatory elements encode the genomic blueprints that ensure the proper
spatiotemporal patterning of gene expression necessary for appropriate development and …
spatiotemporal patterning of gene expression necessary for appropriate development and …
Ever-changing landscapes: transcriptional enhancers in development and evolution
A class of cis-regulatory elements, called enhancers, play a central role in orchestrating
spatiotemporally precise gene-expression programs during development. Consequently …
spatiotemporally precise gene-expression programs during development. Consequently …
Genomic encoding of transcriptional burst kinetics
Mammalian gene expression is inherently stochastic,, and results in discrete bursts of RNA
molecules that are synthesized from each allele,,,–. Although transcription is known to be …
molecules that are synthesized from each allele,,,–. Although transcription is known to be …
Enhancer RNAs are an important regulatory layer of the epigenome
V Sartorelli, SM Lauberth - Nature structural & molecular biology, 2020 - nature.com
Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development
and disease through their regulation of transcription, RNA processing and translation …
and disease through their regulation of transcription, RNA processing and translation …
Dynamic interplay between enhancer–promoter topology and gene activity
A long-standing question in gene regulation is how remote enhancers communicate with
their target promoters, and specifically how chromatin topology dynamically relates to gene …
their target promoters, and specifically how chromatin topology dynamically relates to gene …
Decreased enhancer-promoter proximity accompanying enhancer activation
Enhancers can regulate the promoters of their target genes over very large genomic
distances. It is widely assumed that mechanisms of enhancer action involve the …
distances. It is widely assumed that mechanisms of enhancer action involve the …