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APOC-III: a gatekeeper in controlling triglyceride metabolism
Abstract Purpose of Review Apolipoprotein C-III (ApoC-III) is a widely known player in
triglyceride metabolism, and it has been recently recognized as a polyhedric factor which …
triglyceride metabolism, and it has been recently recognized as a polyhedric factor which …
Triglyceride and triglyceride-rich lipoproteins in atherosclerosis
BH Zhang, F Yin, YN Qiao, SD Guo - Frontiers in Molecular …, 2022 - frontiersin.org
Cardiovascular disease (CVD) is still the leading cause of death globally, and
atherosclerosis is the main pathological basis of CVDs. Low-density lipoprotein cholesterol …
atherosclerosis is the main pathological basis of CVDs. Low-density lipoprotein cholesterol …
Exploring apolipoprotein C-III: pathophysiological and pharmacological relevance
CJ Packard, A Pirillo, S Tsimikas… - Cardiovascular …, 2023 - academic.oup.com
The availability of pharmacological approaches able to effectively reduce circulating LDL
cholesterol (LDL-C) has led to a substantial reduction in the risk of atherosclerosis-related …
cholesterol (LDL-C) has led to a substantial reduction in the risk of atherosclerosis-related …
[HTML][HTML] Apolipoprotein C3: form begets function
KE Bornfeldt - Journal of Lipid Research, 2024 - Elsevier
Increased circulating levels of apolipoprotein C3 (APOC3) predict cardiovascular disease
(CVD) risk in humans, and APOC3 promotes atherosclerosis in mouse models. APOC3's …
(CVD) risk in humans, and APOC3 promotes atherosclerosis in mouse models. APOC3's …
Postprandial metabolism of apolipoproteins B48, B100, C-III, and E in humans with APOC3 loss-of-function mutations
Background Apolipoprotein C-III (apoC-III) is a regulator of triglyceride (TG) metabolism, and
due to its association with risk of cardiovascular disease, is an emergent target for …
due to its association with risk of cardiovascular disease, is an emergent target for …
[HTML][HTML] Multiplexed assays of human disease-relevant mutations reveal UTR dinucleotide composition as a major determinant of RNA stability
JY Su, YL Wang, YT Hsieh, YC Chang, CH Yang… - eLife, 2025 - elifesciences.org
Untranslated regions (UTRs) contain crucial regulatory elements for RNA stability,
translation and localization, so their integrity is indispensable for gene expression …
translation and localization, so their integrity is indispensable for gene expression …
Contribution of circulating Mfge8 to human T2DM and cardiovascular disease
MFGE8 is a major exosome (EV) protein known to mediate inflammation and atherosclerosis
in type 2 diabetes mellitus (T2DM) in animal studies. The pathophysiological role of this …
in type 2 diabetes mellitus (T2DM) in animal studies. The pathophysiological role of this …
Assessing the prediction of type 2 diabetes risk using polygenic and clinical risk scores in South Asian study populations
Background: Genome-wide polygenic risk scores (PRS) have shown high specificity and
sensitivity in predicting type 2 diabetes (T2D) risk in Europeans. However, the PRS-driven …
sensitivity in predicting type 2 diabetes (T2D) risk in Europeans. However, the PRS-driven …
[HTML][HTML] CRISPR-Cas9 in Cardiovascular Medicine: Unlocking New Potential for Treatment
K Bonowicz, D Jerka, K Piekarska, J Olagbaju… - Cells, 2025 - mdpi.com
Cardiovascular diseases (CVDs) remain a significant global health challenge, with many
current treatments addressing symptoms rather than the genetic roots of these conditions …
current treatments addressing symptoms rather than the genetic roots of these conditions …
Insights into causal cardiovascular risk factors from mendelian randomization
Abstract Purpose of the Review This review summarizes major insights into causal risk
factors for cardiovascular disease (CVD) by using Mendelian randomization (MR) to obtain …
factors for cardiovascular disease (CVD) by using Mendelian randomization (MR) to obtain …