The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …

Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the
three principal analytical techniques used in metabolomics (the other two being gas …

Over a billion people across the world experience a high rate of missed disease diagnosis,
an issue that highlights the need for diagnostic tools showing increased accuracy and …

Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Bidirectional signalling between the tumour and stroma shapes tumour aggressiveness and
metastasis. ATF4 is a major effector of the Integrated Stress Response, a homeostatic …

Metabolomics investigates global metabolic alterations associated with chemical, biological,
physiological, or pathological processes. These metabolic changes are measured with …

Background & Aims Rifaximin-α is efficacious for the prevention of recurrent hepatic
encephalopathy (HE), but its mechanism of action remains unclear. We postulated that …

Great strides have been made over the past decade toward comprehensive study of
metabolism. Mass spectrometry (MS) has played a central role by enabling measurement of …

Recently, metabolomics analyses have become increasingly common in the general
scientific community as it is applied in several researches relating to diseases diagnosis …

Highlights•Metabolomics has become a widely applied tool in drug development.•
Metabolomics plays a key role for the identification of physiological response markers.• …