High-throughput determination of RNA structures
RNA performs and regulates a diverse range of cellular processes, with new functional roles
being uncovered at a rapid pace. Interest is growing in how these functions are linked to …
being uncovered at a rapid pace. Interest is growing in how these functions are linked to …
Translational control through ribosome heterogeneity and functional specialization
The conceptual origins of ribosome specialization can be traced back to the earliest days of
molecular biology. Yet, this field has only recently begun to gather momentum, with …
molecular biology. Yet, this field has only recently begun to gather momentum, with …
Cotranscriptional folding of a riboswitch at nucleotide resolution
RNAs can begin to fold immediately as they emerge from RNA polymerase. During
cotranscriptional folding, interactions between nascent RNAs and ligands are able to direct …
cotranscriptional folding, interactions between nascent RNAs and ligands are able to direct …
A noncoding RNA modulator potentiates phenylalanine metabolism in mice
The functional role of long noncoding RNAs (lncRNAs) in inherited metabolic disorders,
including phenylketonuria (PKU), is unknown. Here, we demonstrate that the mouse lncRNA …
including phenylketonuria (PKU), is unknown. Here, we demonstrate that the mouse lncRNA …
Advances in RNA 3D structure modeling using experimental data
RNA is a unique bio-macromolecule that can both record genetic information and perform
biological functions in a variety of molecular processes, including transcription, splicing …
biological functions in a variety of molecular processes, including transcription, splicing …
Computationally reconstructing cotranscriptional RNA folding from experimental data reveals rearrangement of non-native folding intermediates
MY Angela, PM Gasper, L Cheng, LB Lai, S Kaur… - Molecular cell, 2021 - cell.com
The series of RNA folding events that occur during transcription can critically influence
cellular RNA function. Here, we present reconstructing RNA dynamics from data (R2D2), a …
cellular RNA function. Here, we present reconstructing RNA dynamics from data (R2D2), a …
Probing RNA structure in vivo
Highlights•Probing RNA structure in vivo facilitates understanding of its biological
context.•All four RNA nucleobases and protein interaction sites can now be probed in …
context.•All four RNA nucleobases and protein interaction sites can now be probed in …
Strategies to annotate and characterize long noncoding RNAs: advantages and pitfalls
The past decade has seen an explosion of interest in long noncoding RNAs (lncRNAs).
However, despite the massive volume of scientific data implicating these transcripts in a …
However, despite the massive volume of scientific data implicating these transcripts in a …
The chemistry and applications of RNA 2′-OH acylation
RNA is a versatile biomolecule with a broad range of biological functions that go far beyond
its initially described role as a simple information carrier. The development of chemical …
its initially described role as a simple information carrier. The development of chemical …
A ligand-gated strand displacement mechanism for ZTP riboswitch transcription control
Cotranscriptional folding is an obligate step of RNA biogenesis that can guide RNA structure
formation and function through transient intermediate folds. This process is particularly …
formation and function through transient intermediate folds. This process is particularly …