Network propagation: a universal amplifier of genetic associations
Biological networks are powerful resources for the discovery of genes and genetic modules
that drive disease. Fundamental to network analysis is the concept that genes underlying the …
that drive disease. Fundamental to network analysis is the concept that genes underlying the …
Network medicine: a network-based approach to human disease
Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …
Network-based prediction of protein interactions
Despite exceptional experimental efforts to map out the human interactome, the continued
data incompleteness limits our ability to understand the molecular roots of human disease …
data incompleteness limits our ability to understand the molecular roots of human disease …
Predicting perturbation patterns from the topology of biological networks
High-throughput technologies, offering an unprecedented wealth of quantitative data
underlying the makeup of living systems, are changing biology. Notably, the systematic …
underlying the makeup of living systems, are changing biology. Notably, the systematic …
Are innovation and new technologies in precision medicine paving a new era in patients centric care?
Healthcare is undergoing a transformation, and it is imperative to leverage new technologies
to generate new data and support the advent of precision medicine (PM). Recent scientific …
to generate new data and support the advent of precision medicine (PM). Recent scientific …
Integrative approaches for finding modular structure in biological networks
A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …
the cell. To this end, large and complex networks of molecular interactions are being rapidly …
Prediction of protein assemblies, the next frontier: The CASP14‐CAPRI experiment
We present the results for CAPRI Round 50, the fourth joint CASP‐CAPRI protein assembly
prediction challenge. The Round comprised a total of twelve targets, including six dimers …
prediction challenge. The Round comprised a total of twelve targets, including six dimers …
Prioritizing candidate disease genes by network-based boosting of genome-wide association data
Network “guilt by association”(GBA) is a proven approach for identifying novel disease
genes based on the observation that similar mutational phenotypes arise from functionally …
genes based on the observation that similar mutational phenotypes arise from functionally …
Biological and chemical approaches to diseases of proteostasis deficiency
Many diseases appear to be caused by the misregulation of protein maintenance. Such
diseases of protein homeostasis, or “proteostasis,” include loss-of-function diseases (cystic …
diseases of protein homeostasis, or “proteostasis,” include loss-of-function diseases (cystic …
Impact of AlphaFold on structure prediction of protein complexes: The CASP15‐CAPRI experiment
We present the results for CAPRI Round 54, the 5th joint CASP‐CAPRI protein assembly
prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo …
prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo …