Since its discovery 75 years ago, a wealth of knowledge has accumulated on the role of
cardiolipin, the hallmark phospholipid of mitochondria, in bioenergetics and particularly on …

Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their …

The inhibition of protein–protein interactions is a growing strategy in drug development. In
addition to structured regions, many protein loop regions are involved in protein–protein …

The principle of continuity demands the existence of prior molecular states and common
ancestors responsible for extant macromolecular structure. Here, we focus on the …

Optogenetic and chemogenetic control of proteins has revealed otherwise inaccessible
facets of signaling dynamics. Here, we use light-or ligand-sensitive domains to modulate the …

Abstract The Protein Data Bank archive was established in 1971, and recently celebrated its
40th anniversary (Berman et al. in Structure 20: 391, 2012). An analysis of interrelationships …

Cardiolipins (CL) represent unique phospholipids of bacteria and eukaryotic mitochondria
with four acyl chains and two phosphate groups that have been implicated in numerous …

The functional properties of a protein primarily depend on its three-dimensional (3D)
structure. These properties have classically been assigned, visualized and analysed on the …

Control of the G1/S phase transition by the Retinoblastoma (RB) tumor suppressor is critical
for the proliferation of normal cells in tissues, and its inactivation is one of the most …

The transplantation of loops between structurally related proteins is a compelling method to
improve the activity, specificity and stability of enzymes. However, despite the interest of loop …