[HTML][HTML] Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer
MO Krisenko, RL Geahlen - … et Biophysica Acta (BBA)-Molecular Cell …, 2015 - Elsevier
SYK (spleen tyrosine kinase) is well-characterized in the immune system as an essential
enzyme required for signaling through multiple classes of immune recognition receptors. As …
enzyme required for signaling through multiple classes of immune recognition receptors. As …
[HTML][HTML] Syk and pTyr'd: Signaling through the B cell antigen receptor
RL Geahlen - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2009 - Elsevier
The B cell receptor (BCR) transduces antigen binding into alterations in the activity of
intracellular signaling pathways through its ability to recruit and activate the cytoplasmic …
intracellular signaling pathways through its ability to recruit and activate the cytoplasmic …
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
JW Friedberg, J Sharman… - Blood, The Journal …, 2010 - ashpublications.org
Certain malignant B cells rely on B-cell receptor (BCR)–mediated survival signals. Spleen
tyrosine kinase (Syk) initiates and amplifies the BCR signal. In in vivo analyses of B-cell …
tyrosine kinase (Syk) initiates and amplifies the BCR signal. In in vivo analyses of B-cell …
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism
W Dai, W **ang, L Han, Z Yuan, R Wang… - Cancer …, 2022 - Wiley Online Library
Background Abnormal expression of protein tyrosine phosphatases (PTPs) has been
reported to be a crucial cause of cancer. As a member of PTPs, protein tyrosine …
reported to be a crucial cause of cancer. As a member of PTPs, protein tyrosine …
Discovery of recurrent t (6; 7)(p25. 3; q32. 3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing
AL Feldman, A Dogan, DI Smith… - Blood, The Journal …, 2011 - ashpublications.org
The genetics of peripheral T-cell lymphomas are poorly understood. The most well-
characterized abnormalities are translocations involving ALK, occurring in approximately …
characterized abnormalities are translocations involving ALK, occurring in approximately …
SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma
The role of B-cell receptor (BCR)–mediated survival signals in diffuse large B-cell lymphoma
(DLBCL) remains undefined. Ligand-induced BCR signaling induces receptor …
(DLBCL) remains undefined. Ligand-induced BCR signaling induces receptor …
SYK inhibition modulates distinct PI3K/AKT-dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas
B cell receptor (BCR) signaling pathway components represent promising treatment targets
in diffuse large B cell lymphoma (DLBCL) and additional B cell tumors. BCR signaling …
in diffuse large B cell lymphoma (DLBCL) and additional B cell tumors. BCR signaling …
Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation
L Alinari, KV Mahasenan, F Yan… - Blood, The Journal …, 2015 - ashpublications.org
Epigenetic events that are essential drivers of lymphocyte transformation remain
incompletely characterized. We used models of Epstein-Barr virus (EBV)–induced B-cell …
incompletely characterized. We used models of Epstein-Barr virus (EBV)–induced B-cell …
Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells
The protein kinase Syk is a key mediator of proximal B-cell receptor (BCR) signaling.
Following antigen stimulation, Syk is recruited to the BCR and becomes activated by …
Following antigen stimulation, Syk is recruited to the BCR and becomes activated by …
Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia
Studying 830 pre-B ALL cases from four clinical trials, we found that human ALL can be
divided into two fundamentally distinct subtypes based on pre-BCR function. While absent in …
divided into two fundamentally distinct subtypes based on pre-BCR function. While absent in …