Decidualization denotes the transformation of endometrial stromal fibroblasts into
specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix …

Aside from inheriting half of the genome of each of our parents, we are born with a small
number of novel mutations that occurred during gametogenesis and postzygotically. Recent …

Correction of disease-causing mutations in human embryos holds the potential to reduce the
burden of inherited genetic disorders and improve fertility treatments for couples with …

Pregnancy loss is often caused by chromosomal abnormalities of the conceptus. The
prevalence of these abnormalities and the allocation of (ab) normal cells in embryonic and …

CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the
correction of disease-associated alleles in somatic cells. The use of this approach has also …

INTRODUCTION Genomes are spatially organized across length scales from single base
pairs to whole chromosomes. This organization is thought to regulate gene expression and …

Chromosomal instability leading to aneuploidy is pervasive in early human embryos,–and is
considered as a major cause of infertility and pregnancy wastage,. Here we provide several …

Karyotype alterations have emerged as on-target complications from CRISPR-Cas9 genome
editing. However, the events that lead to these karyotypic changes in embryos after Cas9 …

DNA methylation is a crucial layer of epigenetic regulation during mammalian embryonic
development,–. Although the DNA methylome of early human embryos has been analyzed …

Human cleavage-stage embryos frequently acquire chromosomal aneuploidies during
mitosis due to unknown mechanisms. Here, we show that S phase at the 1-cell stage shows …