Cyanobacteria—From the oceans to the potential biotechnological and biomedical applications

SAM Khalifa, ES Shedid, EM Saied, AR Jassbi… - Marine Drugs, 2021 - mdpi.com
Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant
source of novel, bioactive, secondary metabolites, and they are also considered an …

Developments of cyanobacteria for nano-marine drugs: Relevance of nanoformulations in cancer therapies

VK Bajpai, S Shukla, SM Kang, SK Hwang, X Song… - Marine drugs, 2018 - mdpi.com
Current trends in the application of nanomaterials are emerging in the nano-
biotechnological sector for development of medicines. Cyanobacteria (blue-green algae) …

Design, synthesis and evaluation of new quinazolin-4-one derivatives as apoptotic enhancers and autophagy inhibitors with potent antitumor activity

HSA ElZahabi, MS Nafie, D Osman… - European Journal of …, 2021 - Elsevier
This work presents the design and synthesis of a series of new quinazolin-4-one derivatives,
based on the established effectiveness of quinazoline-based small molecules as anticancer …

Drug design strategies with metal-hydroxyquinoline complexes

IM Savić-Gajić, IM Savić - Expert opinion on drug discovery, 2020 - Taylor & Francis
Introduction: 8-hydroxyquinoline derivatives and their complexes with transition metals are
the subject of many studies due to their anticancer, anti-inflammatory, anti-infective, and …

Caenorhabditis elegans as an Infection Model for Pathogenic Mold and Dimorphic Fungi: Applications and Challenges

CS Ahamefule, BC Ezeuduji, JC Ogbonna… - Frontiers in Cellular …, 2021 - frontiersin.org
The threat burden from pathogenic fungi is universal and increasing with alarming high
mortality and morbidity rates from invasive fungal infections. Understanding the virulence …

Molecular target interactions of quinoline derivatives as anticancer agents: A review

V Pradhan, R Kumar, A Mazumder… - Chemical Biology & …, 2023 - Wiley Online Library
One of the leading causes of death worldwide is cancer, which poses substantial risks to
both society and an individual's life. Cancer therapy is still challenging, despite …

Discovery of a novel dibromoquinoline compound exhibiting potent antifungal and antivirulence activity that targets metal ion homeostasis

H Mohammad, NH Elghazawy… - ACS infectious …, 2018 - ACS Publications
Globally, invasive fungal infections pose a significant challenge to modern human medicine
due to the limited number of antifungal drugs and the rise in resistance to current antifungal …

Quinoline and ferrocene conjugates: Synthesis, computational study and biological evaluations

S Maračić, J Lapić, S Djaković… - Applied …, 2019 - Wiley Online Library
Novel O‐alkylated quinoline and N‐alkylated 4‐quinolone derivatives attached to the
ferrocene moiety through 4, 1‐(7a–d, 8a–d and 12a–d) and 1, 4‐disubstituted (9a, 9b, 10a …

Anticancer Activity–Structure Relationship of Quinolinone-Core Compounds: An Overall Review

HK Beker, I Yıldırım - Pharmaceutical Chemistry Journal, 2023 - Springer
Quinolinone/quinoline is one of the most unique structures in the discovery of heterocycles
that have attracted much attention in the field of medicinal chemistry. The basic scaffold of …

Exploring quinolone scaffold: Unravelling the chemistry of anticancer drug design

V Sharma, R Das, DK Mehta… - Mini Reviews in …, 2022 - ingentaconnect.com
Globally, cancer is considered as the major leading cause in burdening the patient's health
care system globally. The growing threat of drug-resistant cancers renders an urgent need to …