Multidrug-resistant bacteria have on overwhelming impact on human health, as they cause
over 670,000 infections and 33,000 deaths annually in the European Union alone. Of these …

Resistance to antimicrobials and particularly multidrug resistance is one of the greatest
challenges in the health system nowadays. The continual increase in the rates of …

Background: The Surgical Infection Society (SIS) published evidence-based guidelines for
the management of intra-abdominal infection (IAI) in 1992, 2002, 2010, and 2017. Here, we …

Gram-negative bacterial resistance to antimicrobials has had an exponential increase at a
global level during the last decades and represent an everyday challenge, especially for the …

Severe/MDR Gram-negative infections continue to be important infections due to their
impact on patient outcomes, especially in critically ill and immunocompromised hosts. The …

Introduction: Doxycycline is an antibiotic with known gastrointestinal (GI) adverse effects.
Esophagitis is the most pronounced among these effects, and might be associated with a …

Objectives To evaluate eravacycline (ERV) activity against Gram-negative and Gram-
positive bacteria collected between 2017 and 2020 from worldwide locations. Methods MIC …

Background Carbapenem-sparing antibiotics are needed urgently for patients with
complicated intra-abdominal infections (cIAIs). Although several novel antibiotics–novel β …

Introduction Oral fluoroquinolones and tetracyclines are known to interact with divalent or
trivalent cation-containing compounds (DTCCs) via chelation. The objective of this study is …

Background Eravacycline is a novel, fully synthetic fluorocycline antibiotic for the treatment
of adults with complicated intra-abdominal infections (cIAIs). However, the efficacy and …