In the era of quantitative proteomics, where mass spectrometry plays a pivotal role, in
particular associated with the use of data‐independent acquisition, it is time to perform an …

High-throughput lysis and proteolytic digestion of biopsy-level tissue specimens is a major
bottleneck for clinical proteomics. Here we describe a detailed protocol of pressure cycling …

There are still unmet needs in finding new technologies for biomedical diagnostic and
industrial applications. A technology allowing the analysis of size and sequence of short …

Proteomics experiments commonly aim to estimate and detect differential abundance across
all expressed proteins. Within this experimental design, some of the most challenging …

Introduction: While selected/multiple-reaction monitoring (SRM or MRM) is considered the
gold standard for quantitative protein measurement, emerging data-independent acquisition …

Formalin‐fixed, paraffin‐embedded (FFPE), biobanked tissue samples offer an invaluable
resource for clinical and biomarker research. Here, we developed a pressure cycling …

CellMinerCDB provides a web-based resource (https://discover. nci. nih. gov/cellminercdb/)
for integrating multiple forms of pharmacological and genomic analyses, and unifying the …

Determination of malignancy in thyroid nodules remains a major diagnostic challenge. Here
we report the feasibility and clinical utility of develo** an AI-defined protein-based …

Only a small percent of human genomic DNA encodes for proteins. Additionally, protein
isoforms variants and chemical modifications are not coded in the genome read by the cell …

Here we describe a proteomic data resource for the NCI-60 cell lines generated by pressure
cycling technology and SWATH mass spectrometry. We developed the DIA-expert software …