One of the open questions in RAS biology is the existence of RAS dimers and their role in
RAF dimerization and activation. The idea of RAS dimers arose from the discovery that RAF …

Phosphatidylserine (PS) is a negatively charged glycerophospholipid found mainly in the
plasma membrane (PM) and in the late secretory/endocytic compartments, where it …

Oncogenic KRAS expression generates a metabolic dependency on aerobic glycolysis,
known as the Warburg effect. We report an effect of increased glycolytic flux that feeds into …

RAS is a signaling protein associated with the cell membrane that is mutated in up to 30% of
human cancers. RAS signaling has been proposed to be regulated by dynamic …

Protein–membrane interactions (PMIs) are ubiquitous in cellular signaling. Initial steps of
signal transduction cascades often rely on transient and dynamic interactions with the inner …

Mutations of rat sarcoma virus (RAS) oncogenes (HRAS, KRAS and NRAS) can contribute to
the development of cancers and genetic disorders (RASopathies). The spatiotemporal …

ABSTRACT Introduction Molecular Dynamics (MD) simulations can support mechanism-
based drug design. Indeed, MD simulations by capturing biomolecule motions at finite …

Phospholipids are lipids that constitute the basic structure of cell membranes. In-depth
research has shown that in addition to supporting cell structures, phospholipids participate …

Protein structure has been well established to play a key role in determining function;
however, intrinsically disordered proteins and regions (IDPs and IDRs) defy this paradigm …

Cellular membranes are critical to the function of membrane proteins, whether they are
associated (peripheral) or embedded (integral) within the bilayer. While detergents have …