T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Lysosomes are composed of soluble and transmembrane proteins that are targeted to
lysosomes in a signal-dependent manner. The majority of soluble acid hydrolases are …

Analysis of the human genome reveals that approximately a third of all open reading frames
code for proteins that enter the endoplasmic reticulum (ER), demonstrating the importance of …

Disulfide bond formation is probably involved in the biogenesis of approximately one third of
human proteins. A central player in this essential process is protein disulfide isomerase or …

Endoplasmic reticulum (ER) stress is of considerable interest to plant biologists because it
occurs in plants subjected to adverse environmental conditions. ER stress responses …

The processing of N-linked glycans determines secretory protein homeostasis in the
eukaryotic cell. Folding and degradation of glycoproteins in the endoplasmic reticulum (ER) …

The endoplasmic reticulum (ER) has a sophisticated quality control (QC) system to eliminate
improperly folded proteins from the secretory pathway. Given that protein folding is such a …

The endoplasmic reticulum (ER) is the cell organelle where secretory and membrane
proteins are synthesized and folded. Correctly folded proteins exit the ER and are …

Most enveloped viruses rely on the host cell endoplasmic reticulum (ER) quality control (QC)
machinery for proper folding of glycoproteins. The key ER α-glucosidases (α-Glu) I and II of …