Photoluminescent nanoparticles for chemical and biological analysis and imaging

WR Algar, M Massey, K Rees, R Higgins… - Chemical …, 2021 - ACS Publications
Research related to the development and application of luminescent nanoparticles (LNPs)
for chemical and biological analysis and imaging is flourishing. Novel materials and new …

Detecting biothreat agents: From current diagnostics to develo** sensor technologies

SA Walper, G Lasarte Aragonés, KE Sapsford… - ACS …, 2018 - ACS Publications
Although a fundamental understanding of the pathogenicity of most biothreat agents has
been elucidated and available treatments have increased substantially over the past …

Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades

JC Breger, JN Vranish, E Oh, MH Stewart… - Nature …, 2023 - nature.com
Access to efficient enzymatic channeling is desired for improving all manner of designer
biocatalysis. We demonstrate that enzymes constituting a multistep cascade can self …

Quantum dot-based molecular beacons for quantitative detection of nucleic acids with CRISPR/Cas (N) nucleases

CM Green, J Spangler, K Susumu, DA Stenger… - ACS …, 2022 - ACS Publications
Strategies utilizing the CRISPR/Cas nucleases Cas13 and Cas12 have shown great
promise in the development of highly sensitive and rapid diagnostic assays for the detection …

Quantum dot–peptide conjugates as energy transfer probes for sensing the proteolytic activity of matrix metalloproteinase-14

Z **, N Dridi, G Palui, V Palomo, JV Jokerst… - Analytical …, 2023 - ACS Publications
We detail the assembly and characterization of quantum dot (QD)− dye conjugates
constructed using a peptide bridge specifically designed to recognize and interact with a …

Assessing the Steric Impact of Surface Ligands on the Proteolytic Turnover of Quantum Dot–Peptide Conjugates

KD Krause, K Rees, WR Algar - ACS Applied Materials & …, 2023 - ACS Publications
Proteases are important biomarkers and targets for the diagnosis and treatment of disease.
The advantageous properties of semiconductor quantum dots (QDs) have made these …

Direct and efficient conjugation of quantum dots to DNA nanostructures with peptide-PNA

CM Green, DA Hastman, D Mathur, K Susumu, E Oh… - ACS …, 2021 - ACS Publications
DNA nanotechnology has proven to be a powerful strategy for the bottom-up preparation of
colloidal nanoparticle (NP) superstructures, enabling the coordination of multiple NPs with …

Enhancing coupled enzymatic activity by colocalization on nanoparticle surfaces: Kinetic evidence for directed channeling of intermediates

JN Vranish, MG Ancona, E Oh, K Susumu… - ACS …, 2018 - ACS Publications
Multistep enzymatic cascades are becoming more prevalent in industrial settings as
engineers strive to synthesize complex products and pharmaceuticals in economical …

Pursuing the promise of enzymatic enhancement with nanoparticle assemblies

JN Vranish, MG Ancona, SA Walper, IL Medintz - Langmuir, 2017 - ACS Publications
The growing emphasis on green chemistry, renewable resources, synthetic biology, regio-
/stereospecific chemical transformations, and nanotechnology for providing new biological …

Small surface, big effects, and big challenges: toward understanding enzymatic activity at the inorganic nanoparticle–substrate interface

WR Algar, T Jeen, M Massey, WJ Peveler, J Asselin - Langmuir, 2018 - ACS Publications
Enzymes are important biomarkers for molecular diagnostics and targets for the action of
drugs. In turn, inorganic nanoparticles (NPs) are of interest as materials for biological …