A minireview on N-acetylcysteine: an old drug with new approaches

IE Dhouib, M Jallouli, A Annabi, N Gharbi, S Elfazaa… - Life sciences, 2016 - Elsevier
Abstract N-acetylcysteine (NAC), a cysteine pro-drug and glutathione precursor has been
used in therapeutic practices for several decades, as a mucolytic agent and for the treatment …

Biomarkers of mercury toxicity: Past, present, and future trends

V Branco, S Caito, M Farina… - Journal of Toxicology …, 2017 - Taylor & Francis
Mercury (Hg) toxicity continues to represent a global health concern. Given that human
populations are mostly exposed to low chronic levels of mercurial compounds …

In vitro antioxidant activity of thiazolidinone derivatives of 1, 3-thiazole and 1, 3, 4-thiadiazole

M Djukic, M Fesatidou, I Xenikakis, A Geronikaki… - Chemico-biological …, 2018 - Elsevier
The initial steps in preclinical drug develo** research concern the synthesis of new
compounds for specific therapeutic use which needs to be confirmed by in vitro and then in …

Cellular and molecular events leading to paraquat-induced apoptosis: mechanistic insights into Parkinson's disease pathophysiology

WZC See, R Naidu, KS Tang - Molecular neurobiology, 2022 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the
cardinal features of tremor, bradykinesia, rigidity, and postural instability, in addition to other …

Alterations in energy/redox metabolism induced by mitochondrial and environmental toxins: a specific role for glucose-6-phosphate-dehydrogenase and the pentose …

S Lei, L Zavala-Flores, A Garcia-Garcia… - ACS chemical …, 2014 - ACS Publications
Parkinson's disease (PD) is a multifactorial disorder with a complex etiology including
genetic risk factors, environmental exposures, and aging. While energy failure and oxidative …

Carvedilol attenuates paraquat-induced lung injury by inhibition of proinflammatory cytokines, chemokine MCP-1, NF-κB activation and oxidative stress mediators

K Amirshahrokhi, AR Khalili - Cytokine, 2016 - Elsevier
Paraquat is a highly toxic herbicide that selectively accumulates in the lungs and causes
pulmonary damage through the oxidative and inflammatory processes. Carvedilol is a …

Protective effects of exogenous β-hydroxybutyrate on paraquat toxicity in rat kidney

T Wei, W Tian, F Liu, G **e - Biochemical and biophysical research …, 2014 - Elsevier
In this study, we demonstrated the protective effects of β-hydroxybutyrate (β-HB) against
paraquat (PQ)-induced kidney injury and elucidated the underlying molecular mechanisms …

Chlorogenic acid protective effects on paraquat‐induced pulmonary oxidative damage and fibrosis in rats

A Larki‐Harchegani, F Fayazbakhsh… - … of Biochemical and …, 2023 - Wiley Online Library
Paraquat (PQ) is a widely used herbicide that can cause severe oxidative and fibrotic
injuries in lung tissue. Due to the antioxidant and anti‐inflammatory properties of …

Paraquat and Parkinson's disease: The molecular crosstalk of upstream signal transduction pathways leading to apoptosis

WZC See, R Naidu, K San Tang - Current Neuropharmacology, 2024 - benthamdirect.com
Parkinson's disease (PD) is a heterogeneous disease involving a complex interaction
between genes and the environment that affects various cellular pathways and neural …

Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium

A Djuric, A Begic, B Gobeljic, I Stanojevic… - Food and Chemical …, 2015 - Elsevier
The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on
oxidative stress (OS), essential metals and androgenic status and morphological changes …