The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

The use of animal models in drug discovery studies presents issues with feasibility and
ethical concerns. To address these limitations, in vitro tissue models have been developed …

Mesenchymal stem cells (MSCs) are increasingly being used in tissue engineering and cell-
based therapies in all fields ranging from orthopedic to cardiovascular medicine. Despite …

Mesenchymal stem/stromal cells (MSC) are typically used to generate bone tissue by a
process resembling intramembranous ossification, ie, by direct osteoblastic differentiation …

In a develo** organism, tissues emerge from coordinated sequences of cell renewal,
differentiation, and assembly that are orchestrated by spatial and temporal gradients of …

Since the discovery of osteoinduction in the early 20th century, innovative biomaterials with
osteoinductive potential have emerged. Over the last 50 years, however, our ability to …

A bone tissue engineering strategy involving the in vitro expansion of cells on a scaffold
before implantation into the body represents a promising alternative to current clinical …

Osteochondral defects (ie, defects which affect both the articular cartilage and underlying
subchondral bone) are often associated with mechanical instability of the joint, and therefore …

Bone marrow is a viscous tissue that resides in the confines of bones and houses the vitally
important pluripotent stem cells. Due to its confinement by bones, the marrow has a unique …

Background The immune contexture predicts prognosis in human colorectal cancer (CRC).
Whereas tumour-infiltrating CD8+ T cells and myeloid CD16+ myeloperoxidase (MPO)+ …