Transcriptional regulation by Nrf2
Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach
Abstract Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …
[HTML][HTML] On the role of 4-hydroxynonenal in health and disease
Polyunsaturated fatty acids are susceptible to peroxidation and they yield various
degradation products, including the main α, β-unsaturated hydroxyalkenal, 4-hydroxy-2, 3 …
degradation products, including the main α, β-unsaturated hydroxyalkenal, 4-hydroxy-2, 3 …
TrxR1 as a potent regulator of the Nrf2-Keap1 response system
Significance: All cells must maintain a balance between oxidants and reductants, while
allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or …
allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or …
Developments in toxicogenomics: understanding and predicting compound-induced toxicity from gene expression data
B Alexander-Dann, LL Pruteanu, E Oerton… - Molecular omics, 2018 - pubs.rsc.org
The toxicogenomics field aims to understand and predict toxicity by using 'omics' data in
order to study systems-level responses to compound treatments. In recent years there has …
order to study systems-level responses to compound treatments. In recent years there has …
Nrf2 induces IL-17D to mediate tumor and virus surveillance
Cells undergoing xenobiotic or oxidative stress activate the transcription factor nuclear factor
erythroid-derived 2-like 2 (Nrf2), which initiates an intrinsic" stress surveillance" pathway. We …
erythroid-derived 2-like 2 (Nrf2), which initiates an intrinsic" stress surveillance" pathway. We …
Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells
Background We previously showed that pancreatic stellate cells (PSC) secreted interleukin
(IL)-6 and promoted pancreatic ductal adenocarcinoma (PDAC) cell proliferation via nuclear …
(IL)-6 and promoted pancreatic ductal adenocarcinoma (PDAC) cell proliferation via nuclear …
NRF2 and the Moirai: Life and death decisions on cell fates
Significance: The transcription factor NRF2 (NF-E2-related factor 2) plays an important role
as a master regulator of the cellular defense system by activating transcriptional programs of …
as a master regulator of the cellular defense system by activating transcriptional programs of …
Signal transducer and activator of transcription 3 and 5 regulate system Xc-and redox balance in human breast cancer cells
K Linher-Melville, S Haftchenary, P Gunning… - Molecular and cellular …, 2015 - Springer
Abstract System Xc-is a cystine/glutamate antiporter that contributes to the maintenance of
cellular redox balance. The human xCT (SLC7A11) gene encodes the functional subunit of …
cellular redox balance. The human xCT (SLC7A11) gene encodes the functional subunit of …
[HTML][HTML] Suppression of AMPK/aak-2 by NRF2/SKN-1 down-regulates autophagy during prolonged oxidative stress
M Kosztelnik, A Kurucz, D Papp, E Jones… - The FASEB …, 2018 - pmc.ncbi.nlm.nih.gov
NF-E2–related factor 2 (NRF2) transcription factor has a fundamental role in cell
homeostasis maintenance as one of the master regulators of oxidative and electrophilic …
homeostasis maintenance as one of the master regulators of oxidative and electrophilic …