Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …

Dimerization-driven activation of the intracellular kinase domains of the epidermal growth
factor receptor (EGFR) upon extracellular ligand binding is crucial to cellular pathways …

The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …

Ionic protein–lipid interactions are critical for the structure and function of membrane
receptors, ion channels, integrins and many other proteins,,,,,,. However, the regulatory …

Integrins are heterodimeric transmembrane adhesion receptors that couple the actin
cytoskeleton to the extracellular environment and bidirectionally relay signals across the cell …

Platelet aggregation is a critical event in thrombus formation and thus has extensive
involvement in physiological and pathological processes. The aggregation response …

Integrin-mediated cell adhesion is important for development, immune responses,
hemostasis and wound healing. Integrins also function as signal transducing receptors that …

Deregulated HER2 is a target of many approved cancer drugs. We analyzed 111,176 patient
tumors and identified recurrent mutations in HER2 transmembrane domain (TMD) and …

The formation of tissues and organs requires cells to adhere to each other and/or to migrate
and polarize in contact with components of the extracellular matrix. The connection between …