There is a large literature on the relationship between obesity and bone. What we can
conclude from this review is that the increase in body weight causes an increase in BMD …

Few investigators think of bone as an endocrine gland, even after the discovery that
osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and …

This review describes the role of bone cells and their surrounding matrix in maintaining
bone strength through the process of bone remodeling. Subsequently, this work focusses on …

Tumor necrosis factor-α (TNF-α) plays an essential role in the regulation of bone
homeostasis in several chronic immune and inflammatory joint diseases, where inhibition of …

Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

Lack of physical activity causes bone loss and fractures not only in elderly people, but also
in bedridden patients or otherwise inactive youth. This is fast becoming one of the most …

MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. In
contrast, we find that Myc haploinsufficient (Myc+/–) mice exhibit increased lifespan. They …

Bone is a mineralized and elastic connective tissue that provides fundamental functions in
the human body, including mechanical support to the muscles and joints, protection of vital …

Background Adolescence is a critical period for bone development, and peak bone mass
may be reached in late adolescence. Boosting bone accumulation at this time can help …

Adaptation of bone to mechanical stresses normally produces a bone architecture that
combines a proper resistance against failure with a minimal use of material. This adaptive …