Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …

Microglia, the resident immune cells of the brain, are increasingly implicated in the
regulation of brain health and disease. Microglia perform multiple functions in the central …

Many aspects of cell homeostasis and integrity are maintained by the nucleotide-binding
oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 …

In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1× C3D2F1 cross,
the Nrf2 activator astaxanthin (Asta) extended the median male lifespan by 12%(p= 0.003 …

Mounting evidence suggests a role for oxidative stress and accumulation of dysfunctional
organelle and misfolded proteins in PD. Autophagosomes mediate the clearance of these …

Activated microglia are divided into pro-inflammatory and anti-inflammatory functional states.
In anti-inflammatory state, activated microglia contribute to phagocytosis, neural repair and …

Diabetic retinopathy (DR) is one of the most prevalent retinal disorders worldwide, and it is a
major cause of vision impairment in individuals of productive age. Research has …

Autophagy is a highly conserved biological process in eukaryotes, which degrades cellular
misfolded proteins, damaged organelles and invasive pathogens in the lysosome …

Background Microglia are innate immune cells in the central nervous system that play a
crucial role in neuroprotection by releasing neurotrophic factors, removing pathogens …

Alzheimer's disease (AD) is the most prevalent neurodegenerative dementia, marked by
progressive cognitive decline and memory impairment. Despite advances in therapeutic …