Recognition in the domain of molecular chirality: from noncovalent interactions to separation of enantiomers

P Peluso, B Chankvetadze - Chemical Reviews, 2022 - ACS Publications
It is not a coincidence that both chirality and noncovalent interactions are ubiquitous in
nature and synthetic molecular systems. Noncovalent interactivity between chiral molecules …

Efficient separation of enantiomers using stereoregular chiral polymers

J Shen, Y Okamoto - Chemical reviews, 2016 - ACS Publications
Biosystems, including ourselves, are very sensitive to the chirality of compounds; for
instance, monosodium L-glutamate is tasty, while its D-isomer is tasteless, and in many …

Recent trends in preparation, investigation and application of polysaccharide-based chiral stationary phases for separation of enantiomers in high-performance liquid …

B Chankvetadze - TrAC Trends in Analytical Chemistry, 2020 - Elsevier
This review article summarizes the recent developments in preparation, investigation and
application of polysaccharide-based chiral stationary phases for the separation of …

Polysaccharide derivatives for chromatographic separation of enantiomers

Y Okamoto, E Yashima - Angewandte Chemie International …, 1998 - Wiley Online Library
The first resolution of enantiomers was performed 150 years ago–mechanically. Today a
powerful method for carrying out this task is HPLC on polysaccharide derivatives as chiral …

Recent developments on polysaccharide-based chiral stationary phases for liquid-phase separation of enantiomers

B Chankvetadze - Journal of chromatography A, 2012 - Elsevier
This paper summarizes recent developments in the synthesis, application and mechanistic
studies on polysaccharide-based chiral stationary phases (CSPs) for liquid phase …

Enantioselective chromatography as a powerful alternative for the preparation of drug enantiomers

ER Francotte - Journal of Chromatography A, 2001 - Elsevier
The preparative separation of enantiomers by chromatography on chiral stationary phases
(CSPs) has been recognized as being a useful alternative to the more conventional …

Structure control of polysaccharide derivatives for efficient separation of enantiomers by chromatography

T Ikai, Y Okamoto - Chemical Reviews, 2009 - ACS Publications
Chirality is a ubiquitous feature in living systems. Today, it is widely recognized that many
biologically interesting compounds, such as drugs, agrochemicals, food additives, and …

Polysaccharide-based chiral stationary phases for high-performance liquid chromatographic enantioseparation

E Yashima - Journal of Chromatography A, 2001 - Elsevier
Recent developments of polysaccharide-based chiral stationary phases (CSPs) for the direct
separation of enantiomers in high-performance liquid chromatography (HPLC) are mainly …

Application of enantioselective separation techniques to bioanalysis of chiral drugs and their metabolites

B Chankvetadze - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Separations of enantiomers are performed for very different purposes. Although the basic
approach to separate enantiomers can be quite general, there may be significant differences …

Preparative supercritical fluid chromatography: a powerful tool for chiral separations

D Speybrouck, E Lipka - Journal of Chromatography A, 2016 - Elsevier
In 2012, the 4 biggest pharmaceutical blockbusters were pure enantiomers and separating
racemic mixtures is now frequently a key step in the development of a new drug. For a long …