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The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
New insight into dyslipidemia‐induced cellular senescence in atherosclerosis
Q **ang, F Tian, J Xu, X Du, S Zhang… - Biological Reviews, 2022 - Wiley Online Library
Atherosclerosis, characterized by lipid‐rich plaques in the arterial wall, is an age‐related
disorder and a leading cause of mortality worldwide. However, the specific mechanisms …
disorder and a leading cause of mortality worldwide. However, the specific mechanisms …
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice
Q Xu, Q Fu, Z Li, H Liu, Y Wang, X Lin, R He… - Nature …, 2021 - nature.com
Ageing-associated functional decline of organs and increased risk for age-related chronic
pathologies is driven in part by the accumulation of senescent cells, which develop the …
pathologies is driven in part by the accumulation of senescent cells, which develop the …
Cellular senescence: from mechanisms to current biomarkers and senotherapies
An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …
related diseases. In the last few decades, several studies have provided evidence of the …
The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
Y Sun, X Wang, T Liu, X Zhu, X Pan - Cell & bioscience, 2022 - Springer
Background The global population of older individuals is growing, and ageing is a key risk
factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells …
factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells …
Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming
Over the past decade, there has been a dramatic increase in efforts to ameliorate aging and
the diseases it causes, with transient expression of nuclear reprogramming factors recently …
the diseases it causes, with transient expression of nuclear reprogramming factors recently …
Gene therapy strategies targeting aging-related diseases
J Yu, T Li, J Zhu - Aging and disease, 2023 - pmc.ncbi.nlm.nih.gov
Rapid advancements have taken place in gene therapy technology. However, effective
methods for treating aging-or age-related chronic diseases, which are often closely related …
methods for treating aging-or age-related chronic diseases, which are often closely related …
Cellular senescence and the host immune system in aging and age-related disorders
Cellular senescence is a complex process involving a close-to-irreversible arrest of the cell
cycle, the acquisition of the senescence-associated secretory phenotype (SASP), as well as …
cycle, the acquisition of the senescence-associated secretory phenotype (SASP), as well as …
Curcumin nanoformulations to combat aging-related diseases
Aging increases the susceptibility to a diverse set of diseases and disorders, including
neurodegeneration, cancer, diabetes, and arthritis. Natural compounds are currently being …
neurodegeneration, cancer, diabetes, and arthritis. Natural compounds are currently being …
Nanocarriers for natural polyphenol senotherapeutics
Senescence is a heterogenous and dynamic process in which various cell types undergo
cell‐cycle arrest due to cellular stressors. While senescence has been implicated in aging …
cell‐cycle arrest due to cellular stressors. While senescence has been implicated in aging …