[HTML][HTML] Focus: skin: current developments in the immunology of psoriasis

F Grän, A Kerstan, E Serfling, M Goebeler… - The Yale journal of …, 2020 - ncbi.nlm.nih.gov
Psoriasis is a frequent inflammatory skin disease. Fundamental research on the
pathogenesis of psoriasis has substantially increased our understanding of skin …

Advances in understanding the immunological pathways in psoriasis

SR Georgescu, M Tampa, C Caruntu, MI Sarbu… - International journal of …, 2019 - mdpi.com
Psoriasis vulgaris is a chronic, immune-mediated, inflammatory, polygenic skin disorder
affecting approximately 2% of the population. It has a great impact on quality of life; patients …

[HTML][HTML] Crosstalk between keratinocytes and T cells in a 3D microenvironment: a model to study inflammatory skin diseases

EH Van Den Bogaard, GS Tjabringa, I Joosten… - Journal of Investigative …, 2014 - Elsevier
The interaction between keratinocytes and immune cells plays a major role in the
development of inflammatory skin diseases like psoriasis and atopic dermatitis …

The roles of toll-like receptor 4, CD33, CD68, CD69, or CD147/EMMPRIN for monocyte activation by the DAMP S100A8/S100A9

A Möller, SL Jauch-Speer, S Gandhi, T Vogl… - Frontiers in …, 2023 - frontiersin.org
The S100A8/A9 heterocomplex is an abundant damage-associated molecular pattern and
mainly expressed by monocytes, inflammatory activated keratinocytes and neutrophilic …

The roles of T cells in psoriasis

P Zhang, Y Su, S Li, H Chen, R Wu, H Wu - Frontiers in Immunology, 2023 - frontiersin.org
Psoriasis is a recurring inflammatory skin condition characterized by scaly, red patches on
the skin. It affects approximately 3% of the US population and is associated with histological …

The role of p38 MAPK in the aetiopathogenesis of psoriasis and psoriatic arthritis

A Mavropoulos, EI Rigopoulou… - Journal of …, 2013 - Wiley Online Library
The pathogenetic mechanisms responsible for the induction of immune‐mediated disorders,
such as psoriasis, remain not well characterized. Molecular signaling pathways are not well …

Discovery of selective inhibitors of endoplasmic reticulum aminopeptidase 1

Z Maben, R Arya, D Rane, WF An… - Journal of medicinal …, 2019 - ACS Publications
ERAP1 is an endoplasmic reticulum-resident zinc aminopeptidase that plays an important
role in the immune system by trimming peptides for loading onto major histocompatibility …

Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I–driven CD8+ T cell response

K Stockenhuber, AN Hegazy, NR West… - Journal of Experimental …, 2018 - rupress.org
Psoriasis is a complex inflammatory skin disease affecting∼ 3% of the population
worldwide. Although type I interferons (IFN-I) are thought to be involved in its pathogenesis …

RNA-seq and flow-cytometry of conventional, scalp, and palmoplantar psoriasis reveal shared and distinct molecular pathways

R Ahn, D Yan, HW Chang, K Lee, S Bhattarai… - Scientific reports, 2018 - nature.com
It has long been recognized that anatomic location is an important feature for defining
distinct subtypes of plaque psoriasis. However, little is known about the molecular …

[HTML][HTML] Involvement of the cytokine TWEAK in the pathogenesis of psoriasis vulgaris, pustular psoriasis, and erythrodermic psoriasis

H Wang, S Wang, L Li, X Wang, C Liu, M Lu, Y **a… - Cytokine, 2021 - Elsevier
Psoriasis is a common chronic inflammatory dermatitis in which various cytokines play a
detrimental role. The cytokine tumor necrosis factor-related weak inducer of apoptosis …