Over three decades have passed since the first report on the expression of CA125 by
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …

Chimeric antigen receptors (CAR) are synthetic receptors that target T cells to cell-surface
antigens and augment T-cell function and persistence. Mesothelin is a cell-surface antigen …

Mesothelin is a tumor antigen that is highly expressed in many human cancers, including
malignant mesothelioma and pancreatic, ovarian, and lung adenocarcinomas. It is an …

Mucins (MUC) protect epithelial barriers from environmental insult to maintain homeostasis.
However, their aberrant overexpression and glycosylation in various malignancies facilitate …

Introduction: MUC16 is overexpressed in multiple cancers and plays an important role in
tumorigenicity and acquired resistance to therapy. Area covered: In this review, we describe …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a
dismal prognosis. While immunotherapy has been deemed a breakthrough treatment for …

Mucosal surfaces line our body cavities and provide the interaction surface between
commensal and pathogenic microbiota and the host. The barrier function of the mucosal …

CAR-T cell therapy targeting CD19 has achieved remarkable success in the treatment of B
cell malignancies, while various solid malignancies are still refractory for lack of suitable …

Pancreatic ductal adenocarcinomas (PDAs) erect physical barriers to chemotherapy and
induce multiple mechanisms of immune suppression, creating a sanctuary for unimpeded …

Mesothelin (MSLN) represents an attractive molecule for targeted cancer therapies. To
identify tumors that might benefit from such therapies, tissue microarrays including 15,050 …