Voltage-gated ion channels (VGICs), including those for Na+, Ca2+ and K+, selectively
permeate ions across the cell membrane in response to changes in membrane potential …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

Voltage-gated sodium (Nav) channels are targeted by a number of widely used and
investigational drugs for the treatment of epilepsy, arrhythmia, pain, and other disorders …

Na v 1.7 represents a preeminent target for next-generation analgesics for its critical role in
pain sensation. Here we report a 2.2-Å resolution cryo-EM structure of wild-type (WT) Na v …

Dihydropyridines (DHP), the most commonly used antihypertensives, function by inhibiting
the L‐type voltage‐gated Ca2+ (Cav) channels. DHP compounds exhibit chirality‐specific …

Transport proteins are essential for cells in allowing the exchange of substances between
cells and their environment across the lipid bilayer forming a tight barrier. Membrane lipids …

Voltage-gated sodium (Na V) channels initiate and propagate action potentials in excitable
tissues to mediate key physiological processes including heart contraction and nervous …

Voltage-gated sodium channels initiate electrical signals and are frequently targeted by
deadly gating-modifier neurotoxins, including tarantula toxins, which trap the voltage sensor …

Electrical signaling is essential for all fast processes in biology, but its molecular
mechanisms have been uncertain. This review article focuses on studies of bacterial sodium …

Over the past decade, the structural biology of membrane proteins (MPs) has taken a new
turn thanks to epoch-making technical progress in single-particle electron cryo-microscopy …