Hepatitis B virus (HBV) infection is the major cause of inflammatory liver disease, of which
the clinical recovery and effective anti-viral therapy is associated with the sustained viral …

T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter
flow cytometry has allowed a simultaneous assessment of the phenotype and multiple …

The liver provides a tolerogenic immune niche exploited by several highly prevalent
pathogens as well as by primary and metastatic tumors. We have sampled healthy and …

Establishing a CD8+ T cell–mediated immune correlate of protection in HIV disease is
crucial to the development of vaccines designed to generate cell-mediated immunity …

The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …

In recent years, a tremendous effort has been devoted to the detailed characterization of the
phenotype and function of distinct T cell subpopulations in humans, as well as to their …

There is an intense interplay between HIV and the immune system, and the literature is
replete with studies describing various immunological phenomena associated with HIV …

Chronic viral infections can appear in two very different forms: those that are typically
immunologically contained after acute symptomatic infection, such as Epstein-Barr virus …

Here, we report on the expression of programmed death (PD)-1 on human virus-specific
CD8+ T cells and the effect of manipulating signaling through PD-1 on the survival …

There is an urgent need to understand the nature of immune responses against SARS-CoV-
2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that …