Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes
Genetically engineered mouse models are commonly preferred for studying the human
disease due to genetic and pathophysiological similarities between mice and humans. In …
disease due to genetic and pathophysiological similarities between mice and humans. In …
Codon bias and heterologous protein expression
The expression of functional proteins in heterologous hosts is a cornerstone of modern
biotechnology. Unfortunately, proteins are often difficult to express outside their original …
biotechnology. Unfortunately, proteins are often difficult to express outside their original …
Temporal evolution of cortical ensembles promoting remote memory retrieval
Memories of fearful events can last a lifetime. The prelimbic (PL) cortex, a subregion of
prefrontal cortex, plays a critical role in fear memory retrieval over time. Most studies have …
prefrontal cortex, plays a critical role in fear memory retrieval over time. Most studies have …
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Most haematopoietic cells renew from adult haematopoietic stem cells (HSCs),,, however,
macrophages in adult tissues can self-maintain independently of HSCs,,,. Progenitors with …
macrophages in adult tissues can self-maintain independently of HSCs,,,. Progenitors with …
Tissue-resident macrophages originate from yolk sac-derived erythro-myeloid progenitors
EG Perdiguero, K Klapproth, C Schulz, K Busch… - Nature, 2014 - pmc.ncbi.nlm.nih.gov
Most haematopoietic cells renew from adult hematopoietic stem cells (HSC) 1–3, however,
macrophages in adult tissues can self-maintain independently of HSC4–7. Progenitors with …
macrophages in adult tissues can self-maintain independently of HSC4–7. Progenitors with …
Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces
Emerging studies indicate that cooperation between neurons and immune cells regulates
antimicrobial immunity, inflammation and tissue homeostasis. For example, a neuronal …
antimicrobial immunity, inflammation and tissue homeostasis. For example, a neuronal …
Fundamental properties of unperturbed haematopoiesis from stem cells in vivo
K Busch, K Klapproth, M Barile, M Flossdorf… - Nature, 2015 - nature.com
Haematopoietic stem cells (HSCs) are widely studied by HSC transplantation into immune-
and blood-cell-depleted recipients. Single HSCs can rebuild the system after …
and blood-cell-depleted recipients. Single HSCs can rebuild the system after …
Piezo1 links mechanical forces to red blood cell volume
Red blood cells (RBCs) experience significant mechanical forces while recirculating, but the
consequences of these forces are not fully understood. Recent work has shown that gain-of …
consequences of these forces are not fully understood. Recent work has shown that gain-of …
Motor skill learning requires active central myelination
Myelin-forming oligodendrocytes (OLs) are formed continuously in the healthy adult brain. In
this work, we study the function of these late-forming cells and the myelin they produce …
this work, we study the function of these late-forming cells and the myelin they produce …
Paneth cells as a site of origin for intestinal inflammation
TE Adolph, MF Tomczak, L Niederreiter, HJ Ko, J Böck… - Nature, 2013 - nature.com
The recognition of autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has
exposed the critical role of autophagy in Crohn's disease. Homozygosity for the highly …
exposed the critical role of autophagy in Crohn's disease. Homozygosity for the highly …