Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …

Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

The view of the lysosome as the terminal end of cellular catabolic pathways has been
challenged by recent studies showing a central role of this organelle in the control of cell …

The biochemical basis for the regulation of fibre-type determination in skeletal muscle is not
well understood. In addition to the expression of particular myofibrillar proteins, type I (slow …

Obesity can cause a decline in contractile function of skeletal muscle, thereby reducing
mobility and promoting obesity-associated health risks. We reviewed the literature to …

The NFAT family of transcription factors encompasses five proteins evolutionarily related to
the Rel/NFκB family (Chytil and Verdine 1996; Graef et al. 2001b). The primordial family …

Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc
proteins into the nucleus, where they cooperate with other proteins to form complexes on …

Skeletal muscle is comprised of heterogeneous muscle fibers that differ in their physiological
and metabolic parameters. It is this diversity that enables different muscle groups to provide …

Skeletal muscle adapts to chronic physical activity by inducing mitochondrial biogenesis and
switching proportions of muscle fibers from type II to type I. Several major factors involved in …

Calcineurin (PP2B) is a calcium/calmodulin-activated, serine-threonine phosphatase that
transmits signals to the nucleus through the dephosphorylation and translocation of nuclear …