Infections of people with complement deficiencies and patients who have undergone splenectomy
S Ram, LA Lewis, PA Rice - Clinical microbiology reviews, 2010 - Am Soc Microbiol
The complement system comprises several fluid-phase and membrane-associated proteins.
Under physiological conditions, activation of the fluid-phase components of complement is …
Under physiological conditions, activation of the fluid-phase components of complement is …
Infectious diseases associated with complement deficiencies
JE Figueroa, P Densen - Clinical microbiology reviews, 1991 - Am Soc Microbiol
The complement system consists of both plasma and membrane proteins. The former
influence the inflammatory response, immune modulation, and host defense. The latter are …
influence the inflammatory response, immune modulation, and host defense. The latter are …
Systemic lupus erythematosus, complement deficiency, and apoptosis
There are many links between the complement system and the autoimmune disease
systemic lupus erythematosus (SLE). Soon after the identification of antinuclear antibodies …
systemic lupus erythematosus (SLE). Soon after the identification of antinuclear antibodies …
Infectious complications of biological and small molecule targeted immunomodulatory therapies
The past 2 decades have seen a revolution in our approach to therapeutic
immunosuppression. We have moved from relying on broadly active traditional medications …
immunosuppression. We have moved from relying on broadly active traditional medications …
Meningococcal disease and the complement system
LA Lewis, S Ram - Virulence, 2014 - Taylor & Francis
Despite considerable advances in the understanding of the pathogenesis of meningococcal
disease, this infection remains a major cause of morbidity and mortality globally. The role of …
disease, this infection remains a major cause of morbidity and mortality globally. The role of …
Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody
S Gulati, FJ Beurskens, BJ de Kreuk, M Roza… - PLoS …, 2019 - journals.plos.org
Multidrug-resistant Neisseria gonorrhoeae is a global health problem. Monoclonal antibody
(mAb) 2C7 recognizes a gonococcal lipooligosaccharide epitope that is expressed by> 95 …
(mAb) 2C7 recognizes a gonococcal lipooligosaccharide epitope that is expressed by> 95 …
Gonococcal infections in neonates and young children
CR Woods - Seminars in pediatric infectious diseases, 2005 - Elsevier
Gonorrhea has been recognized since antiquity, and more than 60 million new cases occur
yearly worldwide. Much has been learned about the molecular pathogenesis of infection by …
yearly worldwide. Much has been learned about the molecular pathogenesis of infection by …
Experimental gonococcal urethritis and reinfection with homologous gonococci in male volunteers
KA Schmidt, H Schneider, JA Lindstrom… - Sexually transmitted …, 2001 - journals.lww.com
Experimental Gonococcal Urethritis and Reinfection with Homo... : Sexually Transmitted
Diseases Experimental Gonococcal Urethritis and Reinfection with Homologous Gonococci in …
Diseases Experimental Gonococcal Urethritis and Reinfection with Homologous Gonococci in …
Preclinical efficacy of a lipooligosaccharide peptide mimic candidate gonococcal vaccine
The global spread of multidrug-resistant strains of Neisseria gonorrhoeae constitutes a
public health emergency. With limited antibiotic treatment options, there is an urgent need …
public health emergency. With limited antibiotic treatment options, there is an urgent need …
A meta-analysis to quantify the risk of disseminated gonococcal infection with Porin B serotype
G Welch, GW Reed, PA Rice… - Open forum infectious …, 2024 - academic.oup.com
The escalating rates of gonorrhea globally are associated with higher numbers of
disseminated gonococcal infection (DGI). Expression of the PorB1A allele of the major outer …
disseminated gonococcal infection (DGI). Expression of the PorB1A allele of the major outer …