Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

A standard goal of medicinal chemists has been to discover efficient and potent drug
candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive …

Arginine is one of the most versatile amino acids in animal cells, serving as a precursor for
the synthesis not only of proteins but also of nitric oxide, urea, polyamines, proline …

Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …

Boronic acid compounds have been used, because of their unique structural features, for the
development of potent enzyme inhibitors, boron neutron capture agents for cancer therapy …

Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …

The use of boron in small-molecule pharmaceuticals is increasing. Boron's ubiquitous
occurrence in nature and the recent success of a boronic acid drug (Velcade®) in the clinic …

▪ Abstract The metal-activated hydroxide ion is a critical nucleophile in metalloenzymes that
catalyze hydrolysis or hydration reactions. The most common metal used is zinc; …

There is increasing evidence that upregulation of arginase contributes to impaired
endothelial function in aging. In this study, we demonstrate that arginase upregulation leads …

Boranes and borohydride reagents have found utility in synthesis routes to a number of
pharmaceutical and other products. Boron reagents have become increasingly important for …